Amlodipine reduces blood pressure and hadache fquency in cocaine-dependent outpatients

Robert Malcolm, Jiangang (Jason) Liao, Melissa Michel, Kristina Cochran, Wesley Pye, Derik Yeager, Perry V. Halushka

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Blood pressure and headache frequency were evaluated in normotensive male and female cocaine-dependent patients (N=43) participating in a placebo-controlled, double-blind trial of amlodipine for the treatment of cocaine dependence. Amlodipine produced a significant reduction in both systolic (p=0.04) and diastolic (p<=0.01) blood pressures without producing dizziness or faintness. Placebo subjects had about three times the frequency of headaches compared to the amlodipine-treated subjects (p<=0.004). The high frequency of headaches reported by cocaine-dependent individuals was significantly reduced by amlodipine and may reflect improved cerebrovascular tone.

Original languageEnglish (US)
Pages (from-to)415-419
Number of pages5
JournalJournal of Psychoactive Drugs
Issue number4
StatePublished - 2002

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Psychology(all)


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