Amphiphilic polyphosphazenes as membrane materials: influence of side group on radiation cross-linking

H. R. Allcock; M. Gebura; S. Kwon; T. X. Neenan

doi:10.1016/0142-9612(88)90045-2

Amphiphilic polyphosphazenes as membrane materials: influence of side group on radiation cross-linking

H. R. Allcock, M. Gebura, S. Kwon, T. X. Neenan

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

The amphiphilic mixed-substituent polyphosphazenes, [NP(OCH₂CF₃)_x (NHCH₃)_y]_n and [NP(OC₆H₅)_x (NHCH₃)_y]_n, have been prepared by the sequential replacement of chlorine in [NPCI₂]_n by trifluoroethoxide or phenoxide and methylamine. Thin films of these species were cross-linked by exposure to γ radiation and the semipermeability of the resultant membranes was monitored. The radiation-induced cross-linking and membrane-forming properties of these polymers were compared with those of the single substituent polymers, [NP(OCH₂CF₃)_z]_n, [NP(OC₆,H₅)₂]_n, and [NP(NHCH₃)₂]_n. The radiation-cross-linking process appeared to involve free radical reactions at the methyl groups of the methylamino substituants. The possible utility of these materials in biomedical research is discussed.

Original language	English (US)
Pages (from-to)	500-508
Number of pages	9
Journal	Biomaterials
Volume	9
Issue number	6
DOIs	https://doi.org/10.1016/0142-9612(88)90045-2
State	Published - Nov 1988

All Science Journal Classification (ASJC) codes

Bioengineering
Ceramics and Composites
Biophysics
Biomaterials
Mechanics of Materials

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@article{791872272a2148a8a61e700752926277,

title = "Amphiphilic polyphosphazenes as membrane materials: influence of side group on radiation cross-linking",

abstract = "The amphiphilic mixed-substituent polyphosphazenes, [NP(OCH2CF3)x (NHCH3)y]n and [NP(OC6H5)x (NHCH3)y]n, have been prepared by the sequential replacement of chlorine in [NPCI2]n by trifluoroethoxide or phenoxide and methylamine. Thin films of these species were cross-linked by exposure to γ radiation and the semipermeability of the resultant membranes was monitored. The radiation-induced cross-linking and membrane-forming properties of these polymers were compared with those of the single substituent polymers, [NP(OCH2CF3)z]n, [NP(OC6,H5)2]n, and [NP(NHCH3)2]n. The radiation-cross-linking process appeared to involve free radical reactions at the methyl groups of the methylamino substituants. The possible utility of these materials in biomedical research is discussed.",

author = "Allcock, {H. R.} and M. Gebura and S. Kwon and Neenan, {T. X.}",

note = "Funding Information: This work was supported by the USA Public Health Service through grant no. 5ROl HLI 1418 provided through the National Heart, Lung and Blood Institute. Contact angle measurements were carried out in the laboratory of Dr G.M. Whitesides at Harvard University. We gratefully acknowledge the contribution of J.J. Bonner, who carried out the y irradiations. The technical assistance provided by D.S. Strickler and R. Walsh is also acknowledged.",

year = "1988",

month = nov,

doi = "10.1016/0142-9612(88)90045-2",

language = "English (US)",

volume = "9",

pages = "500--508",

journal = "Biomaterials",

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T1 - Amphiphilic polyphosphazenes as membrane materials

T2 - influence of side group on radiation cross-linking

AU - Allcock, H. R.

AU - Gebura, M.

AU - Kwon, S.

AU - Neenan, T. X.

N1 - Funding Information: This work was supported by the USA Public Health Service through grant no. 5ROl HLI 1418 provided through the National Heart, Lung and Blood Institute. Contact angle measurements were carried out in the laboratory of Dr G.M. Whitesides at Harvard University. We gratefully acknowledge the contribution of J.J. Bonner, who carried out the y irradiations. The technical assistance provided by D.S. Strickler and R. Walsh is also acknowledged.

PY - 1988/11

Y1 - 1988/11

N2 - The amphiphilic mixed-substituent polyphosphazenes, [NP(OCH2CF3)x (NHCH3)y]n and [NP(OC6H5)x (NHCH3)y]n, have been prepared by the sequential replacement of chlorine in [NPCI2]n by trifluoroethoxide or phenoxide and methylamine. Thin films of these species were cross-linked by exposure to γ radiation and the semipermeability of the resultant membranes was monitored. The radiation-induced cross-linking and membrane-forming properties of these polymers were compared with those of the single substituent polymers, [NP(OCH2CF3)z]n, [NP(OC6,H5)2]n, and [NP(NHCH3)2]n. The radiation-cross-linking process appeared to involve free radical reactions at the methyl groups of the methylamino substituants. The possible utility of these materials in biomedical research is discussed.

AB - The amphiphilic mixed-substituent polyphosphazenes, [NP(OCH2CF3)x (NHCH3)y]n and [NP(OC6H5)x (NHCH3)y]n, have been prepared by the sequential replacement of chlorine in [NPCI2]n by trifluoroethoxide or phenoxide and methylamine. Thin films of these species were cross-linked by exposure to γ radiation and the semipermeability of the resultant membranes was monitored. The radiation-induced cross-linking and membrane-forming properties of these polymers were compared with those of the single substituent polymers, [NP(OCH2CF3)z]n, [NP(OC6,H5)2]n, and [NP(NHCH3)2]n. The radiation-cross-linking process appeared to involve free radical reactions at the methyl groups of the methylamino substituants. The possible utility of these materials in biomedical research is discussed.

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JO - Biomaterials

JF - Biomaterials

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Amphiphilic polyphosphazenes as membrane materials: influence of side group on radiation cross-linking

Abstract

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