Abstract
An in silico and an in vitro analyses on the binding of Amphotericin B to Sclerotium rolfsii lectin (SRL) were carried out. The in silico analysis indicates that the drug binds on the outer surface of the lectin by interacting with six amino acids (Asp77, Gln98, Asn100, Arg101, Arg107 and Tyr112) at a distance of ~3Å and has an overall free energy of binding of -8.5kcal/mol. This complex was prepared and found to be water-soluble. The determination of in vitro antifungal activity suggests that the complex is fungistatic in nature.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 137-140 |
| Number of pages | 4 |
| Journal | International Journal of Pharmacy and Pharmaceutical Sciences |
| Volume | 3 |
| Issue number | SUPPL. 3 |
| State | Published - 2011 |
All Science Journal Classification (ASJC) codes
- Pharmacology
- Pharmaceutical Science