Amygdala Activation and Emotional Processing in Adolescents at Risk for Substance Use Disorders

Dawn L. Lindsay; Stefan Pajtek; Ralph E. Tarter; Elizabeth C. Long; Duncan B. Clark

doi:10.1080/1067828X.2014.889515

Amygdala Activation and Emotional Processing in Adolescents at Risk for Substance Use Disorders

Dawn L. Lindsay
, Stefan Pajtek
, Ralph E. Tarter
, Elizabeth C. Long
, Duncan B. Clark

Edna Bennett Pierce Prevention Research Center (PRC)

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Studies are needed that examine neurobiological characteristics in high-risk individuals prior to substance use disorder (SUD) development. In this pilot study, 4 adolescent subjects at high risk for SUD (having at least 1 parent with an SUD) were compared with 4 adolescent reference subjects on a cortico-limbic reactivity paradigm, where they were presented with affect-laden faces or geometric shapes. Functional magnetic resonance imaging was used to measure cortical activation in response to these stimuli. High-risk subjects, compared to low-risk, exhibited greater left amygdala activation (t = 2.76, df = 6, p = 0.03), suggesting they may exhibit hyperresponsivity of the amygdala in response to emotional stimuli.

Original language	English (US)
Pages (from-to)	200-204
Number of pages	5
Journal	Journal of Child and Adolescent Substance Abuse
Volume	23
Issue number	3
DOIs	https://doi.org/10.1080/1067828X.2014.889515
State	Published - May 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Social Psychology
Education
General Psychology
Public Health, Environmental and Occupational Health

Access to Document

10.1080/1067828X.2014.889515

Cite this

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title = "Amygdala Activation and Emotional Processing in Adolescents at Risk for Substance Use Disorders",

abstract = "Studies are needed that examine neurobiological characteristics in high-risk individuals prior to substance use disorder (SUD) development. In this pilot study, 4 adolescent subjects at high risk for SUD (having at least 1 parent with an SUD) were compared with 4 adolescent reference subjects on a cortico-limbic reactivity paradigm, where they were presented with affect-laden faces or geometric shapes. Functional magnetic resonance imaging was used to measure cortical activation in response to these stimuli. High-risk subjects, compared to low-risk, exhibited greater left amygdala activation (t = 2.76, df = 6, p = 0.03), suggesting they may exhibit hyperresponsivity of the amygdala in response to emotional stimuli.",

author = "Lindsay, \{Dawn L.\} and Stefan Pajtek and Tarter, \{Ralph E.\} and Long, \{Elizabeth C.\} and Clark, \{Duncan B.\}",

note = "Funding Information: Funding for this study was provided by grants from NIH (P50DA005605, R21AA017312, K01DA018698, and U01AA021690) and the Commonwealth of Pennsylvania (PA-HEAL SPH00010).",

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AU - Tarter, Ralph E.

AU - Long, Elizabeth C.

AU - Clark, Duncan B.

N1 - Funding Information: Funding for this study was provided by grants from NIH (P50DA005605, R21AA017312, K01DA018698, and U01AA021690) and the Commonwealth of Pennsylvania (PA-HEAL SPH00010).

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AB - Studies are needed that examine neurobiological characteristics in high-risk individuals prior to substance use disorder (SUD) development. In this pilot study, 4 adolescent subjects at high risk for SUD (having at least 1 parent with an SUD) were compared with 4 adolescent reference subjects on a cortico-limbic reactivity paradigm, where they were presented with affect-laden faces or geometric shapes. Functional magnetic resonance imaging was used to measure cortical activation in response to these stimuli. High-risk subjects, compared to low-risk, exhibited greater left amygdala activation (t = 2.76, df = 6, p = 0.03), suggesting they may exhibit hyperresponsivity of the amygdala in response to emotional stimuli.

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Amygdala Activation and Emotional Processing in Adolescents at Risk for Substance Use Disorders

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

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