An active transport system in the blood-brain barrier may reduce levodopa availability

Richard A. Hawkins; Ashwini Mokashi; Ian A. Simpson

doi:10.1016/j.expneurol.2005.04.008

An active transport system in the blood-brain barrier may reduce levodopa availability

Richard A. Hawkins, Ashwini Mokashi, Ian A. Simpson

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Levodopa, the primary drug used to treat patients with Parkinson's disease, is transported into the brain by the facilitative amino acid transporter (L1). We present here an unanticipated discovery: levodopa may be pumped out of the brain by a Na⁺-dependent transport system that couples the naturally occurring Na⁺ gradient existing between the brain's extracellular fluid and the cytoplasm of capillary endothelial cells. The activity of this system reduces the net availability of levodopa.

Original language	English (US)
Pages (from-to)	267-271
Number of pages	5
Journal	Experimental Neurology
Volume	195
Issue number	1
DOIs	https://doi.org/10.1016/j.expneurol.2005.04.008
State	Published - Sep 2005

All Science Journal Classification (ASJC) codes

Neurology
Developmental Neuroscience

Access to Document

10.1016/j.expneurol.2005.04.008

Cite this

@article{b699d228ea2e4807bf9e33386e31bd93,

title = "An active transport system in the blood-brain barrier may reduce levodopa availability",

abstract = "Levodopa, the primary drug used to treat patients with Parkinson's disease, is transported into the brain by the facilitative amino acid transporter (L1). We present here an unanticipated discovery: levodopa may be pumped out of the brain by a Na+-dependent transport system that couples the naturally occurring Na+ gradient existing between the brain's extracellular fluid and the cytoplasm of capillary endothelial cells. The activity of this system reduces the net availability of levodopa.",

author = "Hawkins, {Richard A.} and Ashwini Mokashi and Simpson, {Ian A.}",

note = "Funding Information: This work was supported by grants from the National Institute of Neurological Disorders and Stroke, NS 041405 (I.A.S.), and The International Glutamate Technical Committee (R.A.H.).",

year = "2005",

month = sep,

doi = "10.1016/j.expneurol.2005.04.008",

language = "English (US)",

volume = "195",

pages = "267--271",

journal = "Experimental Neurology",

issn = "0014-4886",

publisher = "Academic Press Inc.",

number = "1",

}

TY - JOUR

T1 - An active transport system in the blood-brain barrier may reduce levodopa availability

AU - Hawkins, Richard A.

AU - Mokashi, Ashwini

AU - Simpson, Ian A.

N1 - Funding Information: This work was supported by grants from the National Institute of Neurological Disorders and Stroke, NS 041405 (I.A.S.), and The International Glutamate Technical Committee (R.A.H.).

PY - 2005/9

Y1 - 2005/9

N2 - Levodopa, the primary drug used to treat patients with Parkinson's disease, is transported into the brain by the facilitative amino acid transporter (L1). We present here an unanticipated discovery: levodopa may be pumped out of the brain by a Na+-dependent transport system that couples the naturally occurring Na+ gradient existing between the brain's extracellular fluid and the cytoplasm of capillary endothelial cells. The activity of this system reduces the net availability of levodopa.

AB - Levodopa, the primary drug used to treat patients with Parkinson's disease, is transported into the brain by the facilitative amino acid transporter (L1). We present here an unanticipated discovery: levodopa may be pumped out of the brain by a Na+-dependent transport system that couples the naturally occurring Na+ gradient existing between the brain's extracellular fluid and the cytoplasm of capillary endothelial cells. The activity of this system reduces the net availability of levodopa.

UR - http://www.scopus.com/inward/record.url?scp=23644452116&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23644452116&partnerID=8YFLogxK

U2 - 10.1016/j.expneurol.2005.04.008

DO - 10.1016/j.expneurol.2005.04.008

M3 - Article

C2 - 15925365

AN - SCOPUS:23644452116

SN - 0014-4886

VL - 195

SP - 267

EP - 271

JO - Experimental Neurology

JF - Experimental Neurology

IS - 1

ER -

An active transport system in the blood-brain barrier may reduce levodopa availability

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this