@inproceedings{7587bc02f0a3453b805e1a7189197832,
title = "An age-based multiscale mathematical model of the hepatitis C virus life-cycle during infection and therapy: Including translation and replication",
abstract = "The dynamics of hepatitis C virus (HCV) RNA during translation and replication were added to an age-based multiscale mathematical model of HCV infection and treatment. The model allows the study of the production of HCV inside infected cells, which are later released as virus in the plasma, available to infect other cells. This is the first model to our knowledge to consider both positive and negative strands of HCV RNA with an age-based multiscale approach. Simulation of the effectiveness of direct acting antiviral (DAA) drugs in blocking HCV RNA intracellular production and release of new virions, and enhancing their depletion were performed. Changes on the set of parameters allowed the validation of the model comparing it to distinct experiments: in vitro and in vivo under therapy.",
author = "Quintela, {B. M.} and Conway, {J. M.} and Hyman, {J. M.} and Reis, {R. F.} and {dos Santos}, {R. W.} and M. Lobosco and Perelson, {A. S.}",
note = "Funding Information: This work was developed with the support of CAPES Proc. number 99999.002789/2014-00 and the Center for Nonlinear Studies, Los Alamos National Laboratory. Publisher Copyright: {\textcopyright} Springer Nature Singapore Pte Ltd. 2017. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.; 7th Latin American Congress on Biomedical Engineering, CLAIB 2016 ; Conference date: 26-10-2016 Through 28-10-2016",
year = "2017",
doi = "10.1007/978-981-10-4086-3_128",
language = "English (US)",
isbn = "9789811040856",
series = "IFMBE Proceedings",
publisher = "Springer Verlag",
pages = "508--511",
editor = "John Bustamante and Sierra, {Daniel A.} and Isnardo Torres",
booktitle = "7th Latin American Congress on Biomedical Engineering, CLAIB 2016",
address = "Germany",
}
