An age-based multiscale mathematical model of the hepatitis C virus life-cycle during infection and therapy: Including translation and replication

B. M. Quintela; J. M. Conway; J. M. Hyman; R. F. Reis; R. W. dos Santos; M. Lobosco; A. S. Perelson

doi:10.1007/978-981-10-4086-3_128

An age-based multiscale mathematical model of the hepatitis C virus life-cycle during infection and therapy: Including translation and replication

B. M. Quintela
, J. M. Conway
, J. M. Hyman
, R. F. Reis
, R. W. dos Santos
, M. Lobosco
, A. S. Perelson

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

5 Scopus citations

Abstract

The dynamics of hepatitis C virus (HCV) RNA during translation and replication were added to an age-based multiscale mathematical model of HCV infection and treatment. The model allows the study of the production of HCV inside infected cells, which are later released as virus in the plasma, available to infect other cells. This is the first model to our knowledge to consider both positive and negative strands of HCV RNA with an age-based multiscale approach. Simulation of the effectiveness of direct acting antiviral (DAA) drugs in blocking HCV RNA intracellular production and release of new virions, and enhancing their depletion were performed. Changes on the set of parameters allowed the validation of the model comparing it to distinct experiments: in vitro and in vivo under therapy.

Original language	English (US)
Title of host publication	7th Latin American Congress on Biomedical Engineering, CLAIB 2016
Editors	John Bustamante, Daniel A. Sierra, Isnardo Torres
Publisher	Springer Verlag
Pages	508-511
Number of pages	4
ISBN (Print)	9789811040856
DOIs	https://doi.org/10.1007/978-981-10-4086-3_128
State	Published - 2017
Event	7th Latin American Congress on Biomedical Engineering, CLAIB 2016 - Bucaramanga, Santander, Colombia Duration: Oct 26 2016 → Oct 28 2016

Publication series

Name	IFMBE Proceedings
Volume	60
ISSN (Print)	1680-0737

Other

Other	7th Latin American Congress on Biomedical Engineering, CLAIB 2016
Country/Territory	Colombia
City	Bucaramanga, Santander
Period	10/26/16 → 10/28/16

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Bioengineering
Biomedical Engineering

Access to Document

10.1007/978-981-10-4086-3_128

Cite this

Quintela, B. M., Conway, J. M., Hyman, J. M., Reis, R. F., dos Santos, R. W., Lobosco, M., & Perelson, A. S. (2017). An age-based multiscale mathematical model of the hepatitis C virus life-cycle during infection and therapy: Including translation and replication. In J. Bustamante, D. A. Sierra, & I. Torres (Eds.), 7th Latin American Congress on Biomedical Engineering, CLAIB 2016 (pp. 508-511). (IFMBE Proceedings; Vol. 60). Springer Verlag. https://doi.org/10.1007/978-981-10-4086-3_128

Quintela, B. M. ; Conway, J. M. ; Hyman, J. M. et al. / An age-based multiscale mathematical model of the hepatitis C virus life-cycle during infection and therapy : Including translation and replication. 7th Latin American Congress on Biomedical Engineering, CLAIB 2016. editor / John Bustamante ; Daniel A. Sierra ; Isnardo Torres. Springer Verlag, 2017. pp. 508-511 (IFMBE Proceedings).

@inproceedings{7587bc02f0a3453b805e1a7189197832,

title = "An age-based multiscale mathematical model of the hepatitis C virus life-cycle during infection and therapy: Including translation and replication",

abstract = "The dynamics of hepatitis C virus (HCV) RNA during translation and replication were added to an age-based multiscale mathematical model of HCV infection and treatment. The model allows the study of the production of HCV inside infected cells, which are later released as virus in the plasma, available to infect other cells. This is the first model to our knowledge to consider both positive and negative strands of HCV RNA with an age-based multiscale approach. Simulation of the effectiveness of direct acting antiviral (DAA) drugs in blocking HCV RNA intracellular production and release of new virions, and enhancing their depletion were performed. Changes on the set of parameters allowed the validation of the model comparing it to distinct experiments: in vitro and in vivo under therapy.",

author = "Quintela, \{B. M.\} and Conway, \{J. M.\} and Hyman, \{J. M.\} and Reis, \{R. F.\} and \{dos Santos\}, \{R. W.\} and M. Lobosco and Perelson, \{A. S.\}",

note = "Funding Information: This work was developed with the support of CAPES Proc. number 99999.002789/2014-00 and the Center for Nonlinear Studies, Los Alamos National Laboratory. Publisher Copyright: {\textcopyright} Springer Nature Singapore Pte Ltd. 2017. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.; 7th Latin American Congress on Biomedical Engineering, CLAIB 2016 ; Conference date: 26-10-2016 Through 28-10-2016",

year = "2017",

doi = "10.1007/978-981-10-4086-3\_128",

language = "English (US)",

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publisher = "Springer Verlag",

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booktitle = "7th Latin American Congress on Biomedical Engineering, CLAIB 2016",

address = "Germany",

}

Quintela, BM, Conway, JM, Hyman, JM, Reis, RF, dos Santos, RW, Lobosco, M & Perelson, AS 2017, An age-based multiscale mathematical model of the hepatitis C virus life-cycle during infection and therapy: Including translation and replication. in J Bustamante, DA Sierra & I Torres (eds), 7th Latin American Congress on Biomedical Engineering, CLAIB 2016. IFMBE Proceedings, vol. 60, Springer Verlag, pp. 508-511, 7th Latin American Congress on Biomedical Engineering, CLAIB 2016, Bucaramanga, Santander, Colombia, 10/26/16. https://doi.org/10.1007/978-981-10-4086-3_128

An age-based multiscale mathematical model of the hepatitis C virus life-cycle during infection and therapy: Including translation and replication. / Quintela, B. M.; Conway, J. M.; Hyman, J. M. et al.
7th Latin American Congress on Biomedical Engineering, CLAIB 2016. ed. / John Bustamante; Daniel A. Sierra; Isnardo Torres. Springer Verlag, 2017. p. 508-511 (IFMBE Proceedings; Vol. 60).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Reis, R. F.

AU - dos Santos, R. W.

AU - Lobosco, M.

AU - Perelson, A. S.

N1 - Funding Information: This work was developed with the support of CAPES Proc. number 99999.002789/2014-00 and the Center for Nonlinear Studies, Los Alamos National Laboratory. Publisher Copyright: © Springer Nature Singapore Pte Ltd. 2017. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2017

Y1 - 2017

N2 - The dynamics of hepatitis C virus (HCV) RNA during translation and replication were added to an age-based multiscale mathematical model of HCV infection and treatment. The model allows the study of the production of HCV inside infected cells, which are later released as virus in the plasma, available to infect other cells. This is the first model to our knowledge to consider both positive and negative strands of HCV RNA with an age-based multiscale approach. Simulation of the effectiveness of direct acting antiviral (DAA) drugs in blocking HCV RNA intracellular production and release of new virions, and enhancing their depletion were performed. Changes on the set of parameters allowed the validation of the model comparing it to distinct experiments: in vitro and in vivo under therapy.

AB - The dynamics of hepatitis C virus (HCV) RNA during translation and replication were added to an age-based multiscale mathematical model of HCV infection and treatment. The model allows the study of the production of HCV inside infected cells, which are later released as virus in the plasma, available to infect other cells. This is the first model to our knowledge to consider both positive and negative strands of HCV RNA with an age-based multiscale approach. Simulation of the effectiveness of direct acting antiviral (DAA) drugs in blocking HCV RNA intracellular production and release of new virions, and enhancing their depletion were performed. Changes on the set of parameters allowed the validation of the model comparing it to distinct experiments: in vitro and in vivo under therapy.

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SN - 9789811040856

T3 - IFMBE Proceedings

SP - 508

EP - 511

BT - 7th Latin American Congress on Biomedical Engineering, CLAIB 2016

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A2 - Sierra, Daniel A.

A2 - Torres, Isnardo

PB - Springer Verlag

Y2 - 26 October 2016 through 28 October 2016

ER -

Quintela BM, Conway JM, Hyman JM, Reis RF, dos Santos RW, Lobosco M et al. An age-based multiscale mathematical model of the hepatitis C virus life-cycle during infection and therapy: Including translation and replication. In Bustamante J, Sierra DA, Torres I, editors, 7th Latin American Congress on Biomedical Engineering, CLAIB 2016. Springer Verlag. 2017. p. 508-511. (IFMBE Proceedings). doi: 10.1007/978-981-10-4086-3_128

An age-based multiscale mathematical model of the hepatitis C virus life-cycle during infection and therapy: Including translation and replication

Abstract

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UN SDGs

All Science Journal Classification (ASJC) codes

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