An anti-tumor necrosis factor antibody suppresses sleep in rats and rabbits

Satoshi Takahashi; Levente Kapa ́s; Jidong Fang; James M. Krueger

doi:10.1016/0006-8993(95)00609-T

An anti-tumor necrosis factor antibody suppresses sleep in rats and rabbits

Satoshi Takahashi, Levente Kapa ́s, Jidong Fang, James M. Krueger

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Abstract

It is hypothesized that tumor necrosis factor (TNF) is an endogenous sleep-promoting substance. In the present experiments we studied the effects of a monoclonal anti-TNF antibody in rats and rabbits. Seven rats and 14 rabbits were implanted with electroencephalographic electrodes, a brain thermistor and an intracerebroventricular guide cannula. The animals were injected with saline, control IgG, and monoclonal hamster anti-murine-TNF antibodies (TNFab) on 3 separate days. Ten μg TNFab suppressed non-rapid-eye-movement sleep (NREMS) in rats. In rabbits, 2.5 μg TNFab did not affect sleep but decreased brain temperature; in contrast, 25 μg TNFab suppressed NREMS without affecting brain temperature. These results are consistent with the hypothesis that endogenous TNF plays an important role in sleep regulation.

Original language	English (US)
Pages (from-to)	241-244
Number of pages	4
Journal	Brain research
Volume	690
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(95)00609-T
State	Published - Sep 4 1995

All Science Journal Classification (ASJC) codes

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(95)00609-T

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title = "An anti-tumor necrosis factor antibody suppresses sleep in rats and rabbits",

abstract = "It is hypothesized that tumor necrosis factor (TNF) is an endogenous sleep-promoting substance. In the present experiments we studied the effects of a monoclonal anti-TNF antibody in rats and rabbits. Seven rats and 14 rabbits were implanted with electroencephalographic electrodes, a brain thermistor and an intracerebroventricular guide cannula. The animals were injected with saline, control IgG, and monoclonal hamster anti-murine-TNF antibodies (TNFab) on 3 separate days. Ten μg TNFab suppressed non-rapid-eye-movement sleep (NREMS) in rats. In rabbits, 2.5 μg TNFab did not affect sleep but decreased brain temperature; in contrast, 25 μg TNFab suppressed NREMS without affecting brain temperature. These results are consistent with the hypothesis that endogenous TNF plays an important role in sleep regulation.",

author = "Satoshi Takahashi and {Kapa{\' }s}, Levente and Jidong Fang and Krueger, {James M.}",

note = "Funding Information: We thank Ying Wang and Sima Geller for their excellent technical assistance.T he assistanceo f Ms. Maria Swayze is gratefully acknowledgedT. his work was supported in part by the National Institutes of Health (NS-31453 and NS-30514).T he permanenta ddress of Dr. S. Takahashii s: Departmenot f AnesthesiologyU,n iversityo f Hirosaki School of Medicine, Hirosaki 036, Japan.",

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doi = "10.1016/0006-8993(95)00609-T",

language = "English (US)",

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pages = "241--244",

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T1 - An anti-tumor necrosis factor antibody suppresses sleep in rats and rabbits

AU - Takahashi, Satoshi

AU - Kapa ́s, Levente

AU - Fang, Jidong

AU - Krueger, James M.

N1 - Funding Information: We thank Ying Wang and Sima Geller for their excellent technical assistance.T he assistanceo f Ms. Maria Swayze is gratefully acknowledgedT. his work was supported in part by the National Institutes of Health (NS-31453 and NS-30514).T he permanenta ddress of Dr. S. Takahashii s: Departmenot f AnesthesiologyU,n iversityo f Hirosaki School of Medicine, Hirosaki 036, Japan.

PY - 1995/9/4

Y1 - 1995/9/4

N2 - It is hypothesized that tumor necrosis factor (TNF) is an endogenous sleep-promoting substance. In the present experiments we studied the effects of a monoclonal anti-TNF antibody in rats and rabbits. Seven rats and 14 rabbits were implanted with electroencephalographic electrodes, a brain thermistor and an intracerebroventricular guide cannula. The animals were injected with saline, control IgG, and monoclonal hamster anti-murine-TNF antibodies (TNFab) on 3 separate days. Ten μg TNFab suppressed non-rapid-eye-movement sleep (NREMS) in rats. In rabbits, 2.5 μg TNFab did not affect sleep but decreased brain temperature; in contrast, 25 μg TNFab suppressed NREMS without affecting brain temperature. These results are consistent with the hypothesis that endogenous TNF plays an important role in sleep regulation.

AB - It is hypothesized that tumor necrosis factor (TNF) is an endogenous sleep-promoting substance. In the present experiments we studied the effects of a monoclonal anti-TNF antibody in rats and rabbits. Seven rats and 14 rabbits were implanted with electroencephalographic electrodes, a brain thermistor and an intracerebroventricular guide cannula. The animals were injected with saline, control IgG, and monoclonal hamster anti-murine-TNF antibodies (TNFab) on 3 separate days. Ten μg TNFab suppressed non-rapid-eye-movement sleep (NREMS) in rats. In rabbits, 2.5 μg TNFab did not affect sleep but decreased brain temperature; in contrast, 25 μg TNFab suppressed NREMS without affecting brain temperature. These results are consistent with the hypothesis that endogenous TNF plays an important role in sleep regulation.

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JO - Brain research

JF - Brain research

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An anti-tumor necrosis factor antibody suppresses sleep in rats and rabbits

Abstract

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