TY - GEN
T1 - An approach for using modified nucleotides in aqueous DNA computing
AU - Pagano, Angela M.
AU - Gal, Susannah
PY - 2008
Y1 - 2008
N2 - The concept of aqueous computing involves the use of large numbers of initially identical molecules to serve as memory registers in a fluid environment. Here, we consider a new approach to aqueous computing where modified nucleotides are used to 'write' on double-stranded DNA molecules to establish the logical values of true or false for a set of clauses. We introduce an implementation scenario where binding proteins specific to each modification can be used to selectively isolate DNA fragments with these modified nucleotides. In addition, we present initial results showing successful incorporation and detection of modifications as well as separation of modified molecules using binding proteins. As there are millions of molecules with corresponding binding proteins, this approach has the potential to yield unlimited computing power as compared with other aqueous computing methods.
AB - The concept of aqueous computing involves the use of large numbers of initially identical molecules to serve as memory registers in a fluid environment. Here, we consider a new approach to aqueous computing where modified nucleotides are used to 'write' on double-stranded DNA molecules to establish the logical values of true or false for a set of clauses. We introduce an implementation scenario where binding proteins specific to each modification can be used to selectively isolate DNA fragments with these modified nucleotides. In addition, we present initial results showing successful incorporation and detection of modifications as well as separation of modified molecules using binding proteins. As there are millions of molecules with corresponding binding proteins, this approach has the potential to yield unlimited computing power as compared with other aqueous computing methods.
UR - http://www.scopus.com/inward/record.url?scp=49949112827&partnerID=8YFLogxK
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U2 - 10.1007/978-3-540-77962-9_17
DO - 10.1007/978-3-540-77962-9_17
M3 - Conference contribution
AN - SCOPUS:49949112827
SN - 3540779612
SN - 9783540779612
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 161
EP - 169
BT - DNA Computing - 13th International Meeting on DNA Computing, DNA13, Revised Selected Papers
T2 - 13th International Meeting on DNA Computing, DNA13
Y2 - 4 June 2007 through 8 June 2007
ER -