An approach for using modified nucleotides in aqueous DNA computing

Angela M. Pagano, Susannah Gal

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


The concept of aqueous computing involves the use of large numbers of initially identical molecules to serve as memory registers in a fluid environment. Here, we consider a new approach to aqueous computing where modified nucleotides are used to 'write' on double-stranded DNA molecules to establish the logical values of true or false for a set of clauses. We introduce an implementation scenario where binding proteins specific to each modification can be used to selectively isolate DNA fragments with these modified nucleotides. In addition, we present initial results showing successful incorporation and detection of modifications as well as separation of modified molecules using binding proteins. As there are millions of molecules with corresponding binding proteins, this approach has the potential to yield unlimited computing power as compared with other aqueous computing methods.

Original languageEnglish (US)
Title of host publicationDNA Computing - 13th International Meeting on DNA Computing, DNA13, Revised Selected Papers
Number of pages9
StatePublished - 2008
Event13th International Meeting on DNA Computing, DNA13 - Memphis, TN, United States
Duration: Jun 4 2007Jun 8 2007

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume4848 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


Other13th International Meeting on DNA Computing, DNA13
Country/TerritoryUnited States
CityMemphis, TN

All Science Journal Classification (ASJC) codes

  • Theoretical Computer Science
  • General Computer Science


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