Abstract
(Matrix presented) A halogen-selective tandem intramolecular Heck/carbonylation reaction has been developed for the construction of the C,E,F-ring system and the C20 quaternary center found in perophoramidine (1). This process can be effected in good yields in the presence of both the chlorine and bromine atoms found in the natural product. In addition, it is possible to introduce the quaternary center at C4 in a stereoselective manner by a lactone enolate alkylation, using NaH and allyl bromide.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1523-1526 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 5 |
| Issue number | 9 |
| DOIs | |
| State | Published - May 1 2003 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
-
SDG 14 Life Below Water
All Science Journal Classification (ASJC) codes
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
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