An atlas of serpin conformations

James Whisstock, Richard Skinner, Arthur Lesk

Research output: Contribution to journalReview articlepeer-review

166 Scopus citations


The serpins are a family of proteins that inhibit chymotrypsin-like serine proteinases, with an unusual mechanism involving a large conformational change known as the stressed→relaxed (S→R) transition. This article is a guide to the known serpin conformations and their biological significance.

Original languageEnglish (US)
Pages (from-to)63-67
Number of pages5
JournalTrends in Biochemical Sciences
Issue number2
StatePublished - Jan 1 1998

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology


Dive into the research topics of 'An atlas of serpin conformations'. Together they form a unique fingerprint.

Cite this