An atlas of serpin conformations

James Whisstock; Richard Skinner; Arthur M. Lesk

doi:10.1016/S0968-0004(97)01172-9

An atlas of serpin conformations

James Whisstock, Richard Skinner, Arthur M. Lesk

Biochemistry & Molecular Biology

Research output: Contribution to journal › Review article › peer-review

168 Scopus citations

Abstract

The serpins are a family of proteins that inhibit chymotrypsin-like serine proteinases, with an unusual mechanism involving a large conformational change known as the stressed→relaxed (S→R) transition. This article is a guide to the known serpin conformations and their biological significance.

Original language	English (US)
Pages (from-to)	63-67
Number of pages	5
Journal	Trends in Biochemical Sciences
Volume	23
Issue number	2
DOIs	https://doi.org/10.1016/S0968-0004(97)01172-9
State	Published - Feb 1998

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology

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10.1016/S0968-0004(97)01172-9

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title = "An atlas of serpin conformations",

abstract = "The serpins are a family of proteins that inhibit chymotrypsin-like serine proteinases, with an unusual mechanism involving a large conformational change known as the stressed→relaxed (S→R) transition. This article is a guide to the known serpin conformations and their biological significance.",

author = "James Whisstock and Richard Skinner and Lesk, \{Arthur M.\}",

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AU - Whisstock, James

AU - Skinner, Richard

AU - Lesk, Arthur M.

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N2 - The serpins are a family of proteins that inhibit chymotrypsin-like serine proteinases, with an unusual mechanism involving a large conformational change known as the stressed→relaxed (S→R) transition. This article is a guide to the known serpin conformations and their biological significance.

AB - The serpins are a family of proteins that inhibit chymotrypsin-like serine proteinases, with an unusual mechanism involving a large conformational change known as the stressed→relaxed (S→R) transition. This article is a guide to the known serpin conformations and their biological significance.

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U2 - 10.1016/S0968-0004(97)01172-9

DO - 10.1016/S0968-0004(97)01172-9

M3 - Review article

C2 - 9538691

AN - SCOPUS:0032006633

SN - 0968-0004

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EP - 67

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

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An atlas of serpin conformations

Abstract

All Science Journal Classification (ASJC) codes

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