An automated miniaturized creatinine sensing system

Son Vu Hoang Lai, David Gaddes, Srinivas Tadigadapa

Research output: Chapter in Book/Report/Conference proceedingConference contribution


In this paper we report on the recently demonstrated, quartz resonator based thermal biosensor configured as a biomedical instrumentation system for continuous monitoring of kidney function based on the measurement of urinary creatinine excretion. The biosensor consists of a reaction chamber which is physically separated but located in close proximity to a micromachined quartz resonator-based temperature sensor. The highly effective coupling of heat from the reaction chamber to the quartz resonator due to close proximity (10-50 microns) and the extremely high absorption coefficient of quartz in the 8-12 μm wavelength range renders this system into a very sensitive thermal sensor design. The non-contact measurement results in no confounding mass loading effects on the quartz resonator and therefore provides clear calorimetric data. The sensor uses creatinine iminohydrolase enzyme immobilized on polystyrene films designed for disposable use. We have successfully integrated the sensor with a programmable miniaturized fluidic system from LabSmith® Inc. to form a miniaturized test system. In this paper we present the latest results on noncontact thermal sensor configuration integrated with miniature automated fluidic system that is capable of continuous monitoring of kidney function based on the measurement of urinary creatinine excretion.

Original languageEnglish (US)
Title of host publicationIEEE SENSORS 2013 - Proceedings
PublisherIEEE Computer Society
ISBN (Print)9781467346405
StatePublished - 2013
Event12th IEEE SENSORS 2013 Conference - Baltimore, MD, United States
Duration: Nov 4 2013Nov 6 2013

Publication series

NameProceedings of IEEE Sensors


Other12th IEEE SENSORS 2013 Conference
Country/TerritoryUnited States
CityBaltimore, MD

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering


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