An efficient total synthesis of maleimycin

Pratap Singh; Steven M. Weinreb

doi:10.1016/0040-4020(76)87018-4

An efficient total synthesis of maleimycin

Pratap Singh, Steven M. Weinreb

Chemistry

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Maleimycin (1), a minor metabolite of Streptomyces showdoensis possesses antibiotic and antitumor activity but is not available in sufficient quantity from natural sources for complete biological testing. Described is an efficient four step total synthesis of racemic maleimycin from readily available cyclopenten-1,2-dicarboxylic acid, which now makes this metabolite available in quantity.

Original language	English (US)
Pages (from-to)	2379-2380
Number of pages	2
Journal	Tetrahedron
Volume	32
Issue number	20
DOIs	https://doi.org/10.1016/0040-4020(76)87018-4
State	Published - 1976

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/0040-4020(76)87018-4

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title = "An efficient total synthesis of maleimycin",

abstract = "Maleimycin (1), a minor metabolite of Streptomyces showdoensis possesses antibiotic and antitumor activity but is not available in sufficient quantity from natural sources for complete biological testing. Described is an efficient four step total synthesis of racemic maleimycin from readily available cyclopenten-1,2-dicarboxylic acid, which now makes this metabolite available in quantity.",

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AB - Maleimycin (1), a minor metabolite of Streptomyces showdoensis possesses antibiotic and antitumor activity but is not available in sufficient quantity from natural sources for complete biological testing. Described is an efficient four step total synthesis of racemic maleimycin from readily available cyclopenten-1,2-dicarboxylic acid, which now makes this metabolite available in quantity.

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JO - Tetrahedron

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An efficient total synthesis of maleimycin

Abstract

All Science Journal Classification (ASJC) codes

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