An electrothermal micromixer for molecular analysis

Mandy L.Y. Sin; Vinay Gidwani; Vincent Gau; Pak Kin Wong

doi:10.1109/NEMS.2009.5068704

An electrothermal micromixer for molecular analysis

Mandy L.Y. Sin, Vinay Gidwani, Vincent Gau, Pak Kin Wong

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

7 Scopus citations

Abstract

Diffusion is often the rate-limiting step in microfluidic-based biochemical analysis systems. In this paper, an alternative current electrothermal mixer for molecular diagnostic is presented. The mixer consists of a concentric electrode design integrated in a microfluidic cartridge. We investigated the electrothermal flow by visualizing the trajectories of seeded particles. The velocity shows a fourth power voltage dependence and is most efficient in the range of 200-600 kHz. By optimizing the design and operating conditions, we demonstrated enhancement of DNA hybridization with a 60-fold reduction in total assay time.

Original language	English (US)
Title of host publication	4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009
Pages	827-831
Number of pages	5
DOIs	https://doi.org/10.1109/NEMS.2009.5068704
State	Published - 2009
Event	4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009 - Shenzhen, China Duration: Jan 5 2009 → Jan 8 2009

Publication series

Name	4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009

Other

Other	4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009
Country/Territory	China
City	Shenzhen
Period	1/5/09 → 1/8/09

All Science Journal Classification (ASJC) codes

Electrical and Electronic Engineering

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10.1109/NEMS.2009.5068704

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Sin, M. L. Y., Gidwani, V., Gau, V., & Wong, P. K. (2009). An electrothermal micromixer for molecular analysis. In 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009 (pp. 827-831). Article 5068704 (4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009). https://doi.org/10.1109/NEMS.2009.5068704

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title = "An electrothermal micromixer for molecular analysis",

abstract = "Diffusion is often the rate-limiting step in microfluidic-based biochemical analysis systems. In this paper, an alternative current electrothermal mixer for molecular diagnostic is presented. The mixer consists of a concentric electrode design integrated in a microfluidic cartridge. We investigated the electrothermal flow by visualizing the trajectories of seeded particles. The velocity shows a fourth power voltage dependence and is most efficient in the range of 200-600 kHz. By optimizing the design and operating conditions, we demonstrated enhancement of DNA hybridization with a 60-fold reduction in total assay time.",

author = "Sin, {Mandy L.Y.} and Vinay Gidwani and Vincent Gau and Wong, {Pak Kin}",

year = "2009",

doi = "10.1109/NEMS.2009.5068704",

language = "English (US)",

isbn = "9781424446308",

series = "4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009",

pages = "827--831",

booktitle = "4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009",

note = "4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009 ; Conference date: 05-01-2009 Through 08-01-2009",

}

Sin, MLY, Gidwani, V, Gau, V & Wong, PK 2009, An electrothermal micromixer for molecular analysis. in 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009., 5068704, 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009, pp. 827-831, 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009, Shenzhen, China, 1/5/09. https://doi.org/10.1109/NEMS.2009.5068704

An electrothermal micromixer for molecular analysis. / Sin, Mandy L.Y.; Gidwani, Vinay; Gau, Vincent et al.
4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009. 2009. p. 827-831 5068704 (4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - An electrothermal micromixer for molecular analysis

AU - Sin, Mandy L.Y.

AU - Gidwani, Vinay

AU - Gau, Vincent

AU - Wong, Pak Kin

PY - 2009

Y1 - 2009

N2 - Diffusion is often the rate-limiting step in microfluidic-based biochemical analysis systems. In this paper, an alternative current electrothermal mixer for molecular diagnostic is presented. The mixer consists of a concentric electrode design integrated in a microfluidic cartridge. We investigated the electrothermal flow by visualizing the trajectories of seeded particles. The velocity shows a fourth power voltage dependence and is most efficient in the range of 200-600 kHz. By optimizing the design and operating conditions, we demonstrated enhancement of DNA hybridization with a 60-fold reduction in total assay time.

AB - Diffusion is often the rate-limiting step in microfluidic-based biochemical analysis systems. In this paper, an alternative current electrothermal mixer for molecular diagnostic is presented. The mixer consists of a concentric electrode design integrated in a microfluidic cartridge. We investigated the electrothermal flow by visualizing the trajectories of seeded particles. The velocity shows a fourth power voltage dependence and is most efficient in the range of 200-600 kHz. By optimizing the design and operating conditions, we demonstrated enhancement of DNA hybridization with a 60-fold reduction in total assay time.

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DO - 10.1109/NEMS.2009.5068704

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T3 - 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009

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BT - 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009

T2 - 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009

Y2 - 5 January 2009 through 8 January 2009

ER -

An electrothermal micromixer for molecular analysis

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