An expedient reductive method for conversion of ketoximes to the corresponding carbonyl compounds

Max M. Majireck; Jason A. Witek; Steven M. Weinreb

doi:10.1016/j.tetlet.2010.04.131

An expedient reductive method for conversion of ketoximes to the corresponding carbonyl compounds

Max M. Majireck, Jason A. Witek, Steven M. Weinreb

Chemistry

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A wide array of readily prepared pivalates of ketoximes can be converted to the corresponding ketones in good yields by treatment with iron powder in THF containing catalytic amounts of both trimethylsilyl chloride and glacial acetic acid at room temperature for 30 min, followed by a brief aqueous workup.

Original language	English (US)
Pages (from-to)	3555-3557
Number of pages	3
Journal	Tetrahedron Letters
Volume	51
Issue number	27
DOIs	https://doi.org/10.1016/j.tetlet.2010.04.131
State	Published - Jul 7 2010

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2010.04.131

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title = "An expedient reductive method for conversion of ketoximes to the corresponding carbonyl compounds",

abstract = "A wide array of readily prepared pivalates of ketoximes can be converted to the corresponding ketones in good yields by treatment with iron powder in THF containing catalytic amounts of both trimethylsilyl chloride and glacial acetic acid at room temperature for 30 min, followed by a brief aqueous workup.",

author = "Majireck, {Max M.} and Witek, {Jason A.} and Weinreb, {Steven M.}",

note = "Funding Information: We are grateful to the National Institutes of Health ( 9R56GM-087733 ) for the financial support of this research.",

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AU - Majireck, Max M.

AU - Witek, Jason A.

AU - Weinreb, Steven M.

N1 - Funding Information: We are grateful to the National Institutes of Health ( 9R56GM-087733 ) for the financial support of this research.

PY - 2010/7/7

Y1 - 2010/7/7

N2 - A wide array of readily prepared pivalates of ketoximes can be converted to the corresponding ketones in good yields by treatment with iron powder in THF containing catalytic amounts of both trimethylsilyl chloride and glacial acetic acid at room temperature for 30 min, followed by a brief aqueous workup.

AB - A wide array of readily prepared pivalates of ketoximes can be converted to the corresponding ketones in good yields by treatment with iron powder in THF containing catalytic amounts of both trimethylsilyl chloride and glacial acetic acid at room temperature for 30 min, followed by a brief aqueous workup.

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

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ER -

An expedient reductive method for conversion of ketoximes to the corresponding carbonyl compounds

Abstract

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