An identical, complex TP53 mutation arising independently in two unrelated families with diverse cancer profiles: The complexity of interpreting cancer risk in carriers

Keyphrases

• Cancer Risk 100%
• TP53 mutation 100%
• Cancer Signatures 100%
• Germ Cells 40%
• Exon 4 40%
• P53 mutant 40%
• Genetic Risk 20%
• DNA Repair 20%
• Risk Prediction 20%
• Functional Activity 20%
• Genetic Modification 20%
• Duplication 20%
• Frameshift 20%
• Haplotype Analysis 20%
• DNA Replication 20%
• Tumor Protein p53 (TP53) 20%
• Adrenocortical 20%
• Genetic Counseling 20%
• Li-Fraumeni Syndrome 20%
• Complex mutations 20%
• DNA Secondary Structure 20%
• Cancer Predisposition Syndrome 20%
• Hairpin Loop 20%
• Choroid Plexus Tumor 20%
• Cancer Phenotype 20%
• Germline TP53 mutation 20%

Biochemistry, Genetics and Molecular Biology

• Germ Cell 100%
• Germline 100%
• Exon 66%
• P53 66%
• Protein Secondary Structure 33%
• Haplotype 33%
• DNA Synthesis 33%
• Gene Mutation 33%
• DNA Repair 33%
• Genetic Counseling 33%