An Improved Synthesis of Anti-Benzo[c]Phenanthrene-3,4-Diol 1,2-Epoxide via 4-Methoxybenzo[c]Phenanthrene

Bijay Misra; Shantu Amin

doi:10.1021/jo00301a054

An Improved Synthesis of Anti-Benzo[c]Phenanthrene-3,4-Diol 1,2-Epoxide via 4-Methoxybenzo[c]Phenanthrene

Bijay Misra, Shantu Amin

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Benzo[c]phenanthrene (1) is a relatively weak carcino-gen¹widely distributed in the environment.²Metabolism of 1 on the benzo ring occurs almost exclusively at the 3,4-position to give trans-benzo[c]phenanthrene-3,4-diol³(2), the precursor to the bay region benzo[c]-phenanthrene-3,4-diol 1,2-epoxides (BcPhDE). BcPhDE exists as a pair of diastereoisomers: syn-BcPhDE (3).

Original language	English (US)
Pages (from-to)	4478-4480
Number of pages	3
Journal	Journal of Organic Chemistry
Volume	55
Issue number	14
DOIs	https://doi.org/10.1021/jo00301a054
State	Published - 1990

All Science Journal Classification (ASJC) codes

Organic Chemistry

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10.1021/jo00301a054

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title = "An Improved Synthesis of Anti-Benzo[c]Phenanthrene-3,4-Diol 1,2-Epoxide via 4-Methoxybenzo[c]Phenanthrene",

abstract = "Benzo[c]phenanthrene (1) is a relatively weak carcino-gen1widely distributed in the environment.2Metabolism of 1 on the benzo ring occurs almost exclusively at the 3,4-position to give trans-benzo[c]phenanthrene-3,4-diol3(2), the precursor to the bay region benzo[c]-phenanthrene-3,4-diol 1,2-epoxides (BcPhDE). BcPhDE exists as a pair of diastereoisomers: syn-BcPhDE (3).",

author = "Bijay Misra and Shantu Amin",

year = "1990",

doi = "10.1021/jo00301a054",

language = "English (US)",

volume = "55",

pages = "4478--4480",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society",

number = "14",

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T1 - An Improved Synthesis of Anti-Benzo[c]Phenanthrene-3,4-Diol 1,2-Epoxide via 4-Methoxybenzo[c]Phenanthrene

AU - Misra, Bijay

AU - Amin, Shantu

PY - 1990

Y1 - 1990

N2 - Benzo[c]phenanthrene (1) is a relatively weak carcino-gen1widely distributed in the environment.2Metabolism of 1 on the benzo ring occurs almost exclusively at the 3,4-position to give trans-benzo[c]phenanthrene-3,4-diol3(2), the precursor to the bay region benzo[c]-phenanthrene-3,4-diol 1,2-epoxides (BcPhDE). BcPhDE exists as a pair of diastereoisomers: syn-BcPhDE (3).

AB - Benzo[c]phenanthrene (1) is a relatively weak carcino-gen1widely distributed in the environment.2Metabolism of 1 on the benzo ring occurs almost exclusively at the 3,4-position to give trans-benzo[c]phenanthrene-3,4-diol3(2), the precursor to the bay region benzo[c]-phenanthrene-3,4-diol 1,2-epoxides (BcPhDE). BcPhDE exists as a pair of diastereoisomers: syn-BcPhDE (3).

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JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 14

ER -

An Improved Synthesis of Anti-Benzo[c]Phenanthrene-3,4-Diol 1,2-Epoxide via 4-Methoxybenzo[c]Phenanthrene

Abstract

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