Abstract
The synthesis of high specific activity tritium-labeled 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone is reported. This compound was prepared by tritiation of 4-(acetoxymethylnitrosamino)-1-[3-(5-bromo)-pyridyl]-1-butanone (5-BrNNKOAc) in the presence of 10% Pd/C catalyst, yielding a product with a specific activity of 11.9 Ci/mmol. This pathway represents a major improvement over previously published methods.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 445-450 |
| Number of pages | 6 |
| Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
| Volume | 44 |
| Issue number | 6 |
| DOIs | |
| State | Published - 2001 |
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Biochemistry
- Radiology Nuclear Medicine and imaging
- Drug Discovery
- Spectroscopy
- Organic Chemistry
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