TY - JOUR
T1 - An Introduction to the Structure and Function of the Catalytic Core Enzyme of Escherichia coli RNA Polymerase
AU - Sutherland, Catherine
AU - Murakami, Katsuhiko S.
N1 - Publisher Copyright:
© 2018 American Society for Microbiology. All rights reserved
PY - 2018/2
Y1 - 2018/2
N2 - RNA polymerase (RNAP) is the essential enzyme responsible for transcribing genetic information stored in DNA to RNA. Understanding the structure and function of RNAP is important for those who study basic principles in gene expression, such as the mechanism of transcription and its regulation, as well as translational sciences such as antibiotic development. With over a half-century of investigations, there is a wealth of information available on the structure and function of Escherichia coli RNAP. This review introduces the structural features of E. coli RNAP, organized by subunit, giving information on the function, location, and conservation of these features to early stage investigators who have just started their research of E. coli RNAP.
AB - RNA polymerase (RNAP) is the essential enzyme responsible for transcribing genetic information stored in DNA to RNA. Understanding the structure and function of RNAP is important for those who study basic principles in gene expression, such as the mechanism of transcription and its regulation, as well as translational sciences such as antibiotic development. With over a half-century of investigations, there is a wealth of information available on the structure and function of Escherichia coli RNAP. This review introduces the structural features of E. coli RNAP, organized by subunit, giving information on the function, location, and conservation of these features to early stage investigators who have just started their research of E. coli RNAP.
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U2 - 10.1128/ECOSALPLUS.ESP-0004-2018
DO - 10.1128/ECOSALPLUS.ESP-0004-2018
M3 - Review article
C2 - 30109846
AN - SCOPUS:85061503658
SN - 2324-6200
VL - 8
JO - EcoSal Plus
JF - EcoSal Plus
IS - 1
ER -