An Investigation of Working Memory Rehearsal in Multiple Sclerosis Using fMRI

F. G. Hillary; N. D. Chiaravalloti; J. H. Ricker; J. Steffener; B. M. Bly; G. Lange; W. C. Liu; A. J. Kalnin; J. DeLuca

doi:10.1076/jcen.25.7.965.16490

An Investigation of Working Memory Rehearsal in Multiple Sclerosis Using fMRI

F. G. Hillary, N. D. Chiaravalloti, J. H. Ricker, J. Steffener, B. M. Bly, G. Lange, W. C. Liu, A. J. Kalnin, J. DeLuca

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Abstract

The present study examined patterns of cerebral activation during a working memory (WM) rehearsal task in individuals diagnosed with multiple sclerosis (MS) and in healthy adults. BOLD functional magnetic resonance imaging (fMRI) was performed using a 1.5 T GE scanner to assess activation during a WM task adapted from the Sternberg paradigm (Sternberg, 1969). Participants included 8 individuals diagnosed with MS, and 5 healthy controls (HCs) matched for age and education. Task difficulty was manipulated by increasing the length of time that strings of letters were to be rehearsed. Findings revealed increased right prefrontal cortex activation and increased right temporal lobe activation in individuals diagnosed with MS compared to HCs. The potential explanations for increased right hemisphere activation in persons with MS are discussed.

Original language	English (US)
Pages (from-to)	965-978
Number of pages	14
Journal	Journal of Clinical and Experimental Neuropsychology
Volume	25
Issue number	7
DOIs	https://doi.org/10.1076/jcen.25.7.965.16490
State	Published - Oct 2003

All Science Journal Classification (ASJC) codes

Clinical Neurology
Neuropsychology and Physiological Psychology
Neurology
Clinical Psychology

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@article{317b574c6a7644bf9382d3a0d20f1541,

title = "An Investigation of Working Memory Rehearsal in Multiple Sclerosis Using fMRI",

abstract = "The present study examined patterns of cerebral activation during a working memory (WM) rehearsal task in individuals diagnosed with multiple sclerosis (MS) and in healthy adults. BOLD functional magnetic resonance imaging (fMRI) was performed using a 1.5 T GE scanner to assess activation during a WM task adapted from the Sternberg paradigm (Sternberg, 1969). Participants included 8 individuals diagnosed with MS, and 5 healthy controls (HCs) matched for age and education. Task difficulty was manipulated by increasing the length of time that strings of letters were to be rehearsed. Findings revealed increased right prefrontal cortex activation and increased right temporal lobe activation in individuals diagnosed with MS compared to HCs. The potential explanations for increased right hemisphere activation in persons with MS are discussed.",

author = "Hillary, {F. G.} and Chiaravalloti, {N. D.} and Ricker, {J. H.} and J. Steffener and Bly, {B. M.} and G. Lange and Liu, {W. C.} and Kalnin, {A. J.} and J. DeLuca",

note = "Funding Information: This research was supported in part by MS grant MH57272, NIH grant HD07522, NIDRR grant H133P970011, and grants from the Henry H. Kessler Foundation, the Hyde & Watson Foundation, and the F.M. Kirby Foundation.",

year = "2003",

month = oct,

doi = "10.1076/jcen.25.7.965.16490",

language = "English (US)",

volume = "25",

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T1 - An Investigation of Working Memory Rehearsal in Multiple Sclerosis Using fMRI

AU - Hillary, F. G.

AU - Chiaravalloti, N. D.

AU - Ricker, J. H.

AU - Steffener, J.

AU - Bly, B. M.

AU - Lange, G.

AU - Liu, W. C.

AU - Kalnin, A. J.

AU - DeLuca, J.

N1 - Funding Information: This research was supported in part by MS grant MH57272, NIH grant HD07522, NIDRR grant H133P970011, and grants from the Henry H. Kessler Foundation, the Hyde & Watson Foundation, and the F.M. Kirby Foundation.

PY - 2003/10

Y1 - 2003/10

N2 - The present study examined patterns of cerebral activation during a working memory (WM) rehearsal task in individuals diagnosed with multiple sclerosis (MS) and in healthy adults. BOLD functional magnetic resonance imaging (fMRI) was performed using a 1.5 T GE scanner to assess activation during a WM task adapted from the Sternberg paradigm (Sternberg, 1969). Participants included 8 individuals diagnosed with MS, and 5 healthy controls (HCs) matched for age and education. Task difficulty was manipulated by increasing the length of time that strings of letters were to be rehearsed. Findings revealed increased right prefrontal cortex activation and increased right temporal lobe activation in individuals diagnosed with MS compared to HCs. The potential explanations for increased right hemisphere activation in persons with MS are discussed.

AB - The present study examined patterns of cerebral activation during a working memory (WM) rehearsal task in individuals diagnosed with multiple sclerosis (MS) and in healthy adults. BOLD functional magnetic resonance imaging (fMRI) was performed using a 1.5 T GE scanner to assess activation during a WM task adapted from the Sternberg paradigm (Sternberg, 1969). Participants included 8 individuals diagnosed with MS, and 5 healthy controls (HCs) matched for age and education. Task difficulty was manipulated by increasing the length of time that strings of letters were to be rehearsed. Findings revealed increased right prefrontal cortex activation and increased right temporal lobe activation in individuals diagnosed with MS compared to HCs. The potential explanations for increased right hemisphere activation in persons with MS are discussed.

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ER -

An Investigation of Working Memory Rehearsal in Multiple Sclerosis Using fMRI

Abstract

All Science Journal Classification (ASJC) codes

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