TY - JOUR
T1 - An On-chip, multichannel droplet sorter using standing surface acoustic waves
AU - Li, Sixing
AU - Ding, Xiaoyun
AU - Guo, Feng
AU - Chen, Yuchao
AU - Lapsley, Michael Ian
AU - Lin, Sz Chin Steven
AU - Wang, Lin
AU - McCoy, J. Philip
AU - Cameron, Craig E.
AU - Huang, Tony Jun
PY - 2013/6/4
Y1 - 2013/6/4
N2 - The emerging field of droplet microfluidics requires effective on-chip handling and sorting of droplets. In this work, we demonstrate a microfluidic device that is capable of sorting picoliter water-in-oil droplets into multiple outputs using standing surface acoustic waves (SSAW). This device integrates a single-layer microfluidic channel with interdigital transducers (IDTs) to achieve on-chip droplet generation and sorting. Within the SSAW field, water-in-oil droplets experience an acoustic radiation force and are pushed toward the acoustic pressure node. As a result, by tuning the frequency of the SSAW excitation, the position of the pressure nodes can be changed and droplets can be sorted to different outlets at rates up to 222 droplets s-1. With its advantages in simplicity, controllability, versatility, noninvasiveness, and capability to be integrated with other on-chip components such as droplet manipulation and optical detection units, the technique presented here could be valuable for the development of droplet-based micro total analysis systems (μTAS).
AB - The emerging field of droplet microfluidics requires effective on-chip handling and sorting of droplets. In this work, we demonstrate a microfluidic device that is capable of sorting picoliter water-in-oil droplets into multiple outputs using standing surface acoustic waves (SSAW). This device integrates a single-layer microfluidic channel with interdigital transducers (IDTs) to achieve on-chip droplet generation and sorting. Within the SSAW field, water-in-oil droplets experience an acoustic radiation force and are pushed toward the acoustic pressure node. As a result, by tuning the frequency of the SSAW excitation, the position of the pressure nodes can be changed and droplets can be sorted to different outlets at rates up to 222 droplets s-1. With its advantages in simplicity, controllability, versatility, noninvasiveness, and capability to be integrated with other on-chip components such as droplet manipulation and optical detection units, the technique presented here could be valuable for the development of droplet-based micro total analysis systems (μTAS).
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U2 - 10.1021/ac400548d
DO - 10.1021/ac400548d
M3 - Article
C2 - 23647057
AN - SCOPUS:84878664396
SN - 0003-2700
VL - 85
SP - 5468
EP - 5474
JO - Analytical Chemistry
JF - Analytical Chemistry
IS - 11
ER -