An optimization framework for identifying reaction activation/inhibiton or elimination candidates for overproduction in microbial systems

Keyphrases

• Genetic Manipulation 100%
• Overproduction 100%
• Optimization Framework 100%
• Reaction Activation 100%
• Microbial Systems 100%
• Escherichia Coli 66%
• Steady-state Value 66%
• Strain Design 66%
• Computational Model 33%
• Ethanol 33%
• Computational Results 33%
• Ethanol Production 33%
• Experimental Values 33%
• Linear Programming Problem 33%
• Proposed Strategy 33%
• Metabolic Network 33%
• Synergism 33%
• Carbon Flux 33%
• Challenging Problems 33%
• Central Metabolism 33%
• Oxygen Uptake 33%
• Simultaneous Use 33%
• Strength Parameters 33%
• Phosphoglucomutase 33%
• Systemic Analysis 33%
• Binary Variables 33%
• Computational Difficulty 33%
• Steady-state Flux 33%
• Biochemical Production 33%
• Pyruvate Formate Lyase 33%

Biochemistry, Genetics and Molecular Biology

• Genetic Manipulation 100%
• Steady State 100%
• Escherichia coli 66%
• Metabolic Pathway 33%
• Oxygen Consumption 33%
• Downregulation 33%
• Metabolic Network 33%
• Phosphoglucomutase 33%
• Pyruvate Formate Lyase 33%