Analysis of Gene-Gene Interactions

Brian S. Cole; Molly A. Hall; Ryan J. Urbanowicz; Diane Gilbert-Diamond; Jason H. Moore

doi:10.1002/cphg.45

Analysis of Gene-Gene Interactions

Brian S. Cole, Molly A. Hall, Ryan J. Urbanowicz, Diane Gilbert-Diamond, Jason H. Moore

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

The goal of this unit is to introduce epistasis, or gene-gene interactions, as a significant contributor to the genetic architecture of complex traits, including disease susceptibility. This unit begins with an historical overview of the concept of epistasis and the challenges inherent in the identification of potential gene-gene interactions. Then, it reviews statistical and machine learning methods for discovering epistasis in the context of genetic studies of quantitative and categorical traits. This unit concludes with a discussion of meta-analysis, replication, and other topics of active research.

Original language	English (US)
Pages (from-to)	1.14.1-1.14.10
Journal	Current protocols in human genetics
Volume	95
Issue number	1
DOIs	https://doi.org/10.1002/cphg.45
State	Published - Oct 2017

All Science Journal Classification (ASJC) codes

Genetics
Genetics(clinical)

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10.1002/cphg.45

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title = "Analysis of Gene-Gene Interactions",

abstract = "The goal of this unit is to introduce epistasis, or gene-gene interactions, as a significant contributor to the genetic architecture of complex traits, including disease susceptibility. This unit begins with an historical overview of the concept of epistasis and the challenges inherent in the identification of potential gene-gene interactions. Then, it reviews statistical and machine learning methods for discovering epistasis in the context of genetic studies of quantitative and categorical traits. This unit concludes with a discussion of meta-analysis, replication, and other topics of active research.",

author = "Cole, {Brian S.} and Hall, {Molly A.} and Urbanowicz, {Ryan J.} and Diane Gilbert-Diamond and Moore, {Jason H.}",

note = "Funding Information: This work was supported by NIH AI116794 and LM010098. Publisher Copyright: Copyright {\textcopyright} 2017 John Wiley and Sons, Inc.",

year = "2017",

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doi = "10.1002/cphg.45",

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AU - Hall, Molly A.

AU - Urbanowicz, Ryan J.

AU - Gilbert-Diamond, Diane

AU - Moore, Jason H.

PY - 2017/10

Y1 - 2017/10

N2 - The goal of this unit is to introduce epistasis, or gene-gene interactions, as a significant contributor to the genetic architecture of complex traits, including disease susceptibility. This unit begins with an historical overview of the concept of epistasis and the challenges inherent in the identification of potential gene-gene interactions. Then, it reviews statistical and machine learning methods for discovering epistasis in the context of genetic studies of quantitative and categorical traits. This unit concludes with a discussion of meta-analysis, replication, and other topics of active research.

AB - The goal of this unit is to introduce epistasis, or gene-gene interactions, as a significant contributor to the genetic architecture of complex traits, including disease susceptibility. This unit begins with an historical overview of the concept of epistasis and the challenges inherent in the identification of potential gene-gene interactions. Then, it reviews statistical and machine learning methods for discovering epistasis in the context of genetic studies of quantitative and categorical traits. This unit concludes with a discussion of meta-analysis, replication, and other topics of active research.

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Analysis of Gene-Gene Interactions

Abstract

All Science Journal Classification (ASJC) codes

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