TY - JOUR
T1 - Angiogenesis and survival in patients with myelodysplastic syndrome
AU - Savic, Aleksandar
AU - Cemerikic-Martinovic, Vesna
AU - Dovat, Sinisa
AU - Rajic, Nebojsa
AU - Urosevic, Ivana
AU - Sekulic, Borivoj
AU - Kvrgic, Vanja
AU - Popovic, Stevan
PY - 2012/7
Y1 - 2012/7
N2 - Angiogenesis has been implicated in the pathogenesis and prognosis of myelodysplastic syndrome (MDS). In this study, we investigated the relationship between microvessel density (MVD), vascular endothelial growth factor (VEGF) expression, common morphological and clinical factors, and survival in patients with MDS. We examined the MVD of paraffin-embedded bone marrow sections from 70 MDS patients and 31 controls. VEGF expression was determined in 50 patients and 20 controls. The median MVD in MDS patients was significantly higher than that in controls (p=0.025), whereas there was no difference in VEGF expression between MDS patients and controls. In univariate analysis, increased MVD was associated with a shorter survival time (p=0.023). However, in multivariate analysis, MVD was not an independent predictor of survival. The VEGF expression did not influence survival in univariate analysis. Survival was independently influenced by platelet count (p=0.0073), cytogenetic risk category (p=0.022), and transfusion dependence (p=0.0073). Neither MVD nor VEGF expression were predictors for progression to acute myeloid leukemia in univariate analysis. Progression to acute myeloid leukemia was independently influenced only by the cytogenetic risk category (p=0.022). This study confirmed increased MVD in MDS. It does not support an independent prognostic role of angiogenesis in MDS.
AB - Angiogenesis has been implicated in the pathogenesis and prognosis of myelodysplastic syndrome (MDS). In this study, we investigated the relationship between microvessel density (MVD), vascular endothelial growth factor (VEGF) expression, common morphological and clinical factors, and survival in patients with MDS. We examined the MVD of paraffin-embedded bone marrow sections from 70 MDS patients and 31 controls. VEGF expression was determined in 50 patients and 20 controls. The median MVD in MDS patients was significantly higher than that in controls (p=0.025), whereas there was no difference in VEGF expression between MDS patients and controls. In univariate analysis, increased MVD was associated with a shorter survival time (p=0.023). However, in multivariate analysis, MVD was not an independent predictor of survival. The VEGF expression did not influence survival in univariate analysis. Survival was independently influenced by platelet count (p=0.0073), cytogenetic risk category (p=0.022), and transfusion dependence (p=0.0073). Neither MVD nor VEGF expression were predictors for progression to acute myeloid leukemia in univariate analysis. Progression to acute myeloid leukemia was independently influenced only by the cytogenetic risk category (p=0.022). This study confirmed increased MVD in MDS. It does not support an independent prognostic role of angiogenesis in MDS.
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U2 - 10.1007/s12253-012-9495-y
DO - 10.1007/s12253-012-9495-y
M3 - Article
C2 - 22270865
AN - SCOPUS:84863975376
SN - 1219-4956
VL - 18
SP - 681
EP - 690
JO - Pathology and Oncology Research
JF - Pathology and Oncology Research
IS - 3
ER -