Animal models of chemotherapy-induced peripheral neuropathy for hematological malignancies: A review

Xiaoli Lv, Yingwei Mao, Song Cao, Yonghuai Feng

Research output: Contribution to journalReview articlepeer-review

Abstract

Chemotherapy is one of the main treatments for hematologic malignancies. However, chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common long-term toxic reactions in chemotherapy, and the occurrence of CIPN affects patients’ quality of life and can cause interruption of chemotherapy in severe cases, thus reducing the efficacy of chemotherapy. We currently summarize the existing CIPN animal models, including the characteristics of several common animal models such as bortezomib-induced peripheral neuropathy, vincristine-induced peripheral neuropathy, and oxaliplatin-induced peripheral neuropathy. It was found that CIPN may lead to behavioral, histopathological, and neurophysiological changes inducing peripheral neuropathy. However, the mechanism of CIPN has not been fully elucidated, especially the prevention and treatment protocols need to be improved. Therefore, this review article summarizes the progress of research on CIPN animal models and the possible mechanisms and treatment of CIPN.

Original languageEnglish (US)
Pages (from-to)72-89
Number of pages18
JournalIbrain
Volume9
Issue number1
DOIs
StatePublished - Mar 1 2023

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience
  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience
  • Neurology

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