Anion exchange in human erythrocytes has a large activation volume

Victor A. Canfield; Robert I. Macey

doi:10.1016/0005-2736(84)90382-1

Anion exchange in human erythrocytes has a large activation volume

Victor A. Canfield, Robert I. Macey

Department of Pathology and Laboratory Medicine

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Sulfate equilibrium exchange in human red cells has an activation volume of +150±20 cm³/mol over the pressure range 0.1 to 83 MPa (15 to 12000 lb/in²) at 30°C. This value greatly exceeds the expected contribution from sulfate binding to the anion exchanger. We suggest that the activation volume reflects conformational changes during the transport cycle.

Original language	English (US)
Pages (from-to)	379-384
Number of pages	6
Journal	BBA - Biomembranes
Volume	778
Issue number	2
DOIs	https://doi.org/10.1016/0005-2736(84)90382-1
State	Published - Dec 5 1984

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Cell Biology

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10.1016/0005-2736(84)90382-1

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title = "Anion exchange in human erythrocytes has a large activation volume",

abstract = "Sulfate equilibrium exchange in human red cells has an activation volume of +150±20 cm3/mol over the pressure range 0.1 to 83 MPa (15 to 12000 lb/in2) at 30°C. This value greatly exceeds the expected contribution from sulfate binding to the anion exchanger. We suggest that the activation volume reflects conformational changes during the transport cycle.",

author = "Canfield, {Victor A.} and Macey, {Robert I.}",

note = "Funding Information: This work was supported by National Institutes of Health Grant GM-18819.",

year = "1984",

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T1 - Anion exchange in human erythrocytes has a large activation volume

AU - Canfield, Victor A.

AU - Macey, Robert I.

N1 - Funding Information: This work was supported by National Institutes of Health Grant GM-18819.

PY - 1984/12/5

Y1 - 1984/12/5

N2 - Sulfate equilibrium exchange in human red cells has an activation volume of +150±20 cm3/mol over the pressure range 0.1 to 83 MPa (15 to 12000 lb/in2) at 30°C. This value greatly exceeds the expected contribution from sulfate binding to the anion exchanger. We suggest that the activation volume reflects conformational changes during the transport cycle.

AB - Sulfate equilibrium exchange in human red cells has an activation volume of +150±20 cm3/mol over the pressure range 0.1 to 83 MPa (15 to 12000 lb/in2) at 30°C. This value greatly exceeds the expected contribution from sulfate binding to the anion exchanger. We suggest that the activation volume reflects conformational changes during the transport cycle.

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U2 - 10.1016/0005-2736(84)90382-1

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ER -

Anion exchange in human erythrocytes has a large activation volume

Abstract

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