Anisotropic conductivity tensor for irreversible electroporation simulations

Nicholas LaBarbera; Corina Drapaca

doi:10.1007/978-3-319-63552-1_5

Anisotropic conductivity tensor for irreversible electroporation simulations

Nicholas LaBarbera
, Corina Drapaca

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

In the past few years, interest has drastically increased in using surgically inserted electrodes to ablate cancer cells. The treatment is referred to as irreversible electroporation (IRE) and has the advantage of being a minimally invasive procedure that can be used to treat tumors while minimizing damage to surrounding tissue and preserving blood vessels. However, treatment planning is required to ensure the electrodes are placed in the correct location and at the proper voltages to ensure all cancer cells are killed while causing the least amount of damage to healthy cells. Computer simulations are used to develop individual treatment plans. Currently, computer simulations for treatment planning have used an isotropic conductivity that increased as the tissue was electroporated. In this work, we propose using a conductivity tensor in which the conductivity increases more in the direction of the electrical field, and results in an anisotropic conductivity tensor. This slightly alters the predicted ablation zone, and could lead to more accurate simulations.

Original language	English (US)
Title of host publication	Mechanics of Biological Systems, Materials and other topics in Experimental and Applied Mechanics - Proceedings of the 2017 Annual Conference on Experimental and Applied Mechanics
Editors	Martha Grady, Wendy Crone, Pablo Zavattieri, Kathryn Dannemann, Majid Minary
Publisher	Springer New York LLC
Pages	29-35
Number of pages	7
ISBN (Print)	9783319635514
DOIs	https://doi.org/10.1007/978-3-319-63552-1_5
State	Published - Jan 1 2018
Event	Annual Conference and Exposition on Experimental and Applied Mechanics, 2017 - Indianapolis, United States Duration: Jun 12 2017 → Jun 15 2017

Publication series

Name	Conference Proceedings of the Society for Experimental Mechanics Series
Volume	4
ISSN (Print)	2191-5644
ISSN (Electronic)	2191-5652

Other

Other	Annual Conference and Exposition on Experimental and Applied Mechanics, 2017
Country/Territory	United States
City	Indianapolis
Period	6/12/17 → 6/15/17

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

General Engineering
Computational Mechanics
Mechanical Engineering

Access to Document

10.1007/978-3-319-63552-1_5

Cite this

LaBarbera, N., & Drapaca, C. (2018). Anisotropic conductivity tensor for irreversible electroporation simulations. In M. Grady, W. Crone, P. Zavattieri, K. Dannemann, & M. Minary (Eds.), Mechanics of Biological Systems, Materials and other topics in Experimental and Applied Mechanics - Proceedings of the 2017 Annual Conference on Experimental and Applied Mechanics (pp. 29-35). (Conference Proceedings of the Society for Experimental Mechanics Series; Vol. 4). Springer New York LLC. https://doi.org/10.1007/978-3-319-63552-1_5

LaBarbera, Nicholas ; Drapaca, Corina. / Anisotropic conductivity tensor for irreversible electroporation simulations. Mechanics of Biological Systems, Materials and other topics in Experimental and Applied Mechanics - Proceedings of the 2017 Annual Conference on Experimental and Applied Mechanics. editor / Martha Grady ; Wendy Crone ; Pablo Zavattieri ; Kathryn Dannemann ; Majid Minary. Springer New York LLC, 2018. pp. 29-35 (Conference Proceedings of the Society for Experimental Mechanics Series).

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title = "Anisotropic conductivity tensor for irreversible electroporation simulations",

abstract = "In the past few years, interest has drastically increased in using surgically inserted electrodes to ablate cancer cells. The treatment is referred to as irreversible electroporation (IRE) and has the advantage of being a minimally invasive procedure that can be used to treat tumors while minimizing damage to surrounding tissue and preserving blood vessels. However, treatment planning is required to ensure the electrodes are placed in the correct location and at the proper voltages to ensure all cancer cells are killed while causing the least amount of damage to healthy cells. Computer simulations are used to develop individual treatment plans. Currently, computer simulations for treatment planning have used an isotropic conductivity that increased as the tissue was electroporated. In this work, we propose using a conductivity tensor in which the conductivity increases more in the direction of the electrical field, and results in an anisotropic conductivity tensor. This slightly alters the predicted ablation zone, and could lead to more accurate simulations.",

author = "Nicholas LaBarbera and Corina Drapaca",

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booktitle = "Mechanics of Biological Systems, Materials and other topics in Experimental and Applied Mechanics - Proceedings of the 2017 Annual Conference on Experimental and Applied Mechanics",

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LaBarbera, N & Drapaca, C 2018, Anisotropic conductivity tensor for irreversible electroporation simulations. in M Grady, W Crone, P Zavattieri, K Dannemann & M Minary (eds), Mechanics of Biological Systems, Materials and other topics in Experimental and Applied Mechanics - Proceedings of the 2017 Annual Conference on Experimental and Applied Mechanics. Conference Proceedings of the Society for Experimental Mechanics Series, vol. 4, Springer New York LLC, pp. 29-35, Annual Conference and Exposition on Experimental and Applied Mechanics, 2017, Indianapolis, United States, 6/12/17. https://doi.org/10.1007/978-3-319-63552-1_5

Anisotropic conductivity tensor for irreversible electroporation simulations. / LaBarbera, Nicholas; Drapaca, Corina.
Mechanics of Biological Systems, Materials and other topics in Experimental and Applied Mechanics - Proceedings of the 2017 Annual Conference on Experimental and Applied Mechanics. ed. / Martha Grady; Wendy Crone; Pablo Zavattieri; Kathryn Dannemann; Majid Minary. Springer New York LLC, 2018. p. 29-35 (Conference Proceedings of the Society for Experimental Mechanics Series; Vol. 4).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Drapaca, Corina

PY - 2018/1/1

Y1 - 2018/1/1

N2 - In the past few years, interest has drastically increased in using surgically inserted electrodes to ablate cancer cells. The treatment is referred to as irreversible electroporation (IRE) and has the advantage of being a minimally invasive procedure that can be used to treat tumors while minimizing damage to surrounding tissue and preserving blood vessels. However, treatment planning is required to ensure the electrodes are placed in the correct location and at the proper voltages to ensure all cancer cells are killed while causing the least amount of damage to healthy cells. Computer simulations are used to develop individual treatment plans. Currently, computer simulations for treatment planning have used an isotropic conductivity that increased as the tissue was electroporated. In this work, we propose using a conductivity tensor in which the conductivity increases more in the direction of the electrical field, and results in an anisotropic conductivity tensor. This slightly alters the predicted ablation zone, and could lead to more accurate simulations.

AB - In the past few years, interest has drastically increased in using surgically inserted electrodes to ablate cancer cells. The treatment is referred to as irreversible electroporation (IRE) and has the advantage of being a minimally invasive procedure that can be used to treat tumors while minimizing damage to surrounding tissue and preserving blood vessels. However, treatment planning is required to ensure the electrodes are placed in the correct location and at the proper voltages to ensure all cancer cells are killed while causing the least amount of damage to healthy cells. Computer simulations are used to develop individual treatment plans. Currently, computer simulations for treatment planning have used an isotropic conductivity that increased as the tissue was electroporated. In this work, we propose using a conductivity tensor in which the conductivity increases more in the direction of the electrical field, and results in an anisotropic conductivity tensor. This slightly alters the predicted ablation zone, and could lead to more accurate simulations.

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T3 - Conference Proceedings of the Society for Experimental Mechanics Series

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BT - Mechanics of Biological Systems, Materials and other topics in Experimental and Applied Mechanics - Proceedings of the 2017 Annual Conference on Experimental and Applied Mechanics

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ER -

LaBarbera N, Drapaca C. Anisotropic conductivity tensor for irreversible electroporation simulations. In Grady M, Crone W, Zavattieri P, Dannemann K, Minary M, editors, Mechanics of Biological Systems, Materials and other topics in Experimental and Applied Mechanics - Proceedings of the 2017 Annual Conference on Experimental and Applied Mechanics. Springer New York LLC. 2018. p. 29-35. (Conference Proceedings of the Society for Experimental Mechanics Series). doi: 10.1007/978-3-319-63552-1_5

Anisotropic conductivity tensor for irreversible electroporation simulations

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