ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures

Gina M. Story; Andrea M. Peier; Alison J. Reeve; Samer R. Eid; Johannes Mosbacher; Todd R. Hricik; Taryn J. Earley; Anne C. Hergarden; David A. Andersson; Sun Wook Hwang; Peter McIntyre; Tim Jegla; Stuart Bevan; Ardem Patapoutian

doi:10.1016/S0092-8674(03)00158-2

ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures

Gina M. Story, Andrea M. Peier, Alison J. Reeve, Samer R. Eid, Johannes Mosbacher, Todd R. Hricik, Taryn J. Earley, Anne C. Hergarden, David A. Andersson, Sun Wook Hwang, Peter McIntyre, Tim Jegla, Stuart Bevan, Ardem Patapoutian

Research output: Contribution to journal › Article › peer-review

2109 Scopus citations

Abstract

Mammals detect temperature with specialized neurons in the peripheral nervous system. Four TRPV-class channels have been implicated in sensing heat, and one TRPM-class channel in sensing cold. The combined range of temperatures that activate these channels covers a majority of the relevant physiological spectrum sensed by most mammals, with a significant gap in the noxious cold range. Here, we describe the characterization of ANKTM1, a cold-activated channel with a lower activation temperature compared to the cold and menthol receptor, TRPM8. ANKTM1 is a distant family member of TRP channels with very little amino acid similarity to TRPM8. It is found in a subset of nociceptive sensory neurons where it is coexpressed with TRPV1/VR1 (the capsaicin/heat receptor) but not TRPM8. Consistent with the expression of ANKTM1, we identify noxious cold-sensitive sensory neurons that also respond to capsaicin but not to menthol.

Original language	English (US)
Pages (from-to)	819-829
Number of pages	11
Journal	Cell
Volume	112
Issue number	6
DOIs	https://doi.org/10.1016/S0092-8674(03)00158-2
State	Published - Mar 21 2003

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/S0092-8674(03)00158-2

Cite this

Story, G. M., Peier, A. M., Reeve, A. J., Eid, S. R., Mosbacher, J., Hricik, T. R., Earley, T. J., Hergarden, A. C., Andersson, D. A., Hwang, S. W., McIntyre, P., Jegla, T., Bevan, S., & Patapoutian, A. (2003). ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell, 112(6), 819-829. https://doi.org/10.1016/S0092-8674(03)00158-2

@article{57c566a8b9d1442b80935097aaba53eb,

title = "ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures",

abstract = "Mammals detect temperature with specialized neurons in the peripheral nervous system. Four TRPV-class channels have been implicated in sensing heat, and one TRPM-class channel in sensing cold. The combined range of temperatures that activate these channels covers a majority of the relevant physiological spectrum sensed by most mammals, with a significant gap in the noxious cold range. Here, we describe the characterization of ANKTM1, a cold-activated channel with a lower activation temperature compared to the cold and menthol receptor, TRPM8. ANKTM1 is a distant family member of TRP channels with very little amino acid similarity to TRPM8. It is found in a subset of nociceptive sensory neurons where it is coexpressed with TRPV1/VR1 (the capsaicin/heat receptor) but not TRPM8. Consistent with the expression of ANKTM1, we identify noxious cold-sensitive sensory neurons that also respond to capsaicin but not to menthol.",

author = "Story, {Gina M.} and Peier, {Andrea M.} and Reeve, {Alison J.} and Eid, {Samer R.} and Johannes Mosbacher and Hricik, {Todd R.} and Earley, {Taryn J.} and Hergarden, {Anne C.} and Andersson, {David A.} and Hwang, {Sun Wook} and Peter McIntyre and Tim Jegla and Stuart Bevan and Ardem Patapoutian",

note = "Funding Information: We thank Sian Colley, Shelley Halpain, Nancy Hong, Thomas Krucker, Van Lee, Xiaorong Liu, Aziz Moqrich, Matt Petrus, and Jim Watson for valuable contributions and input. Supported in part by grants from the NIH and Novartis. A.P. is a Basil O'Connor and Damon Runyon scholar. ",

year = "2003",

month = mar,

day = "21",

doi = "10.1016/S0092-8674(03)00158-2",

language = "English (US)",

volume = "112",

pages = "819--829",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

number = "6",

}

TY - JOUR

T1 - ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures

AU - Story, Gina M.

AU - Peier, Andrea M.

AU - Reeve, Alison J.

AU - Eid, Samer R.

AU - Mosbacher, Johannes

AU - Hricik, Todd R.

AU - Earley, Taryn J.

AU - Hergarden, Anne C.

AU - Andersson, David A.

AU - Hwang, Sun Wook

AU - McIntyre, Peter

AU - Jegla, Tim

AU - Bevan, Stuart

AU - Patapoutian, Ardem

N1 - Funding Information: We thank Sian Colley, Shelley Halpain, Nancy Hong, Thomas Krucker, Van Lee, Xiaorong Liu, Aziz Moqrich, Matt Petrus, and Jim Watson for valuable contributions and input. Supported in part by grants from the NIH and Novartis. A.P. is a Basil O'Connor and Damon Runyon scholar.

PY - 2003/3/21

Y1 - 2003/3/21

N2 - Mammals detect temperature with specialized neurons in the peripheral nervous system. Four TRPV-class channels have been implicated in sensing heat, and one TRPM-class channel in sensing cold. The combined range of temperatures that activate these channels covers a majority of the relevant physiological spectrum sensed by most mammals, with a significant gap in the noxious cold range. Here, we describe the characterization of ANKTM1, a cold-activated channel with a lower activation temperature compared to the cold and menthol receptor, TRPM8. ANKTM1 is a distant family member of TRP channels with very little amino acid similarity to TRPM8. It is found in a subset of nociceptive sensory neurons where it is coexpressed with TRPV1/VR1 (the capsaicin/heat receptor) but not TRPM8. Consistent with the expression of ANKTM1, we identify noxious cold-sensitive sensory neurons that also respond to capsaicin but not to menthol.

AB - Mammals detect temperature with specialized neurons in the peripheral nervous system. Four TRPV-class channels have been implicated in sensing heat, and one TRPM-class channel in sensing cold. The combined range of temperatures that activate these channels covers a majority of the relevant physiological spectrum sensed by most mammals, with a significant gap in the noxious cold range. Here, we describe the characterization of ANKTM1, a cold-activated channel with a lower activation temperature compared to the cold and menthol receptor, TRPM8. ANKTM1 is a distant family member of TRP channels with very little amino acid similarity to TRPM8. It is found in a subset of nociceptive sensory neurons where it is coexpressed with TRPV1/VR1 (the capsaicin/heat receptor) but not TRPM8. Consistent with the expression of ANKTM1, we identify noxious cold-sensitive sensory neurons that also respond to capsaicin but not to menthol.

UR - http://www.scopus.com/inward/record.url?scp=0345616438&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0345616438&partnerID=8YFLogxK

U2 - 10.1016/S0092-8674(03)00158-2

DO - 10.1016/S0092-8674(03)00158-2

M3 - Article

C2 - 12654248

AN - SCOPUS:0345616438

SN - 0092-8674

VL - 112

SP - 819

EP - 829

JO - Cell

JF - Cell

IS - 6

ER -

ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this