TY - JOUR
T1 - Anogenital dermatitis in patients referred for patch testing
T2 - Retrospective analysis of cross-sectional data from the North American Contact Dermatitis Group, 1994-2004
AU - Warshaw, Erin M.
AU - Furda, Laura M.
AU - Maibach, Howard I.
AU - Rietschel, Robert L.
AU - Fowler, Joseph F.
AU - Belsito, Donald V.
AU - Zug, Kathryn A.
AU - DeLeo, Vincent A.
AU - Marks, James G.
AU - Mathias, C. G.Toby
AU - Pratt, Melanie D.
AU - Sasseville, Denis
AU - Storrs, Frances J.
AU - Taylor, James S.
PY - 2008/6
Y1 - 2008/6
N2 - Objectives: To characterize patients with anogenital dermatitis referred for patch testing by the North American Contact Dermatitis Group, to identify common allergens, and to explore sex associations. Design: Retrospective, cross-sectional analysis of the North American Contact Dermatitis Group database, 1994-2004. Patients: Five hundred seventy-five patients with anogenital signs or symptoms were referred for patch testing; 347 had anogenital disease only. Main Outcome Measure: Currently relevant allergic patch test reaction in patients with anogenital signs or symptoms. Results: Sex percentages and mean age were not significantly different in patients with anogenital involvement only compared with those without anogenital involvement. In patients with anogenital involvement only, a final diagnosis of "other dermatoses" was statistically significantly more common in female patients compared with male patients (n=347; relative risk, 1.99; 95% confidence interval, 1.37-2.91), but the diagnosis of allergic contact dermatitis was not associated with sex. Specific allergens that were statistically significantly more common in patients with anogenital involvement included cinnamal (or cinnamic aldehyde), dibucaine, benzocaine, hydrocortisone-17-butyrate, and budesonide (all P<.005). Those that were statistically significantly less frequent included quaternium-15, cobalt chloride, formaldehyde, p-phenylenediamine, and thiuram mix (all P<.04). Seventy-three patients had anogenital allergic contact dermatitis, defined as anogenital involvement only, allergic contact dermatitis as the only diagnosis, and at least 1 positive reaction of current clinical relevance. In that subgroup, the most common allergen sources were cosmetics, medications, and corticosteroids. Conclusion: In patients in the North American Contact Dermatitis Group with anogenital involvement only, male and female patients were equally likely to have allergic contact dermatitis but female patients were more likely to have other dermatoses. Common allergens and sources consisted of those likely to have contact with the anogenital area.
AB - Objectives: To characterize patients with anogenital dermatitis referred for patch testing by the North American Contact Dermatitis Group, to identify common allergens, and to explore sex associations. Design: Retrospective, cross-sectional analysis of the North American Contact Dermatitis Group database, 1994-2004. Patients: Five hundred seventy-five patients with anogenital signs or symptoms were referred for patch testing; 347 had anogenital disease only. Main Outcome Measure: Currently relevant allergic patch test reaction in patients with anogenital signs or symptoms. Results: Sex percentages and mean age were not significantly different in patients with anogenital involvement only compared with those without anogenital involvement. In patients with anogenital involvement only, a final diagnosis of "other dermatoses" was statistically significantly more common in female patients compared with male patients (n=347; relative risk, 1.99; 95% confidence interval, 1.37-2.91), but the diagnosis of allergic contact dermatitis was not associated with sex. Specific allergens that were statistically significantly more common in patients with anogenital involvement included cinnamal (or cinnamic aldehyde), dibucaine, benzocaine, hydrocortisone-17-butyrate, and budesonide (all P<.005). Those that were statistically significantly less frequent included quaternium-15, cobalt chloride, formaldehyde, p-phenylenediamine, and thiuram mix (all P<.04). Seventy-three patients had anogenital allergic contact dermatitis, defined as anogenital involvement only, allergic contact dermatitis as the only diagnosis, and at least 1 positive reaction of current clinical relevance. In that subgroup, the most common allergen sources were cosmetics, medications, and corticosteroids. Conclusion: In patients in the North American Contact Dermatitis Group with anogenital involvement only, male and female patients were equally likely to have allergic contact dermatitis but female patients were more likely to have other dermatoses. Common allergens and sources consisted of those likely to have contact with the anogenital area.
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U2 - 10.1001/archderm.144.6.749
DO - 10.1001/archderm.144.6.749
M3 - Article
C2 - 18559763
AN - SCOPUS:45349104943
SN - 0003-987X
VL - 144
SP - 749
EP - 755
JO - Archives of Dermatology
JF - Archives of Dermatology
IS - 6
ER -