TY - JOUR
T1 - Anorectic specificity as measured in a choice paradigm in rhesus monkeys
AU - Corwin, Rebecca L.
AU - Schuster, Charles R.
N1 - Funding Information:
The authors gratefully acknowledge Dr. William L. Woolverton for insight and discussions while conducting this study, Dr. Jonathan B. Kamien for programming assistance and encouragement, and Drs. G. P. Smith and J. Gibbs for comments on early versions of this manuscript. This research was supported by NIDA Grant DA-00250.
PY - 1993/5
Y1 - 1993/5
N2 - The present report describes a new procedure for assessing anorectic specificity. Two rhesus monkeys (Macaca mulatta) surgically prepared with indwelling intragastric cathetets were trained in a discrete trial choice paradigm to respond for either food or visual access to a room containing other monkeys. Our hypothesis was that a specific anorectic would reduce only food-maintained responding; responding to open a window would either not be affected or would increase. Caloric preloads, d-amphetamine, (d,l)-fenfluramine, and cholecystokinin octapeptide all decreased food-maintained by window opening. These results demonstrate that choice procedures are useful for assessing anorectic specificity.
AB - The present report describes a new procedure for assessing anorectic specificity. Two rhesus monkeys (Macaca mulatta) surgically prepared with indwelling intragastric cathetets were trained in a discrete trial choice paradigm to respond for either food or visual access to a room containing other monkeys. Our hypothesis was that a specific anorectic would reduce only food-maintained responding; responding to open a window would either not be affected or would increase. Caloric preloads, d-amphetamine, (d,l)-fenfluramine, and cholecystokinin octapeptide all decreased food-maintained by window opening. These results demonstrate that choice procedures are useful for assessing anorectic specificity.
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U2 - 10.1016/0091-3057(93)90096-C
DO - 10.1016/0091-3057(93)90096-C
M3 - Article
C2 - 8516352
AN - SCOPUS:0027192057
SN - 0091-3057
VL - 45
SP - 131
EP - 141
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
IS - 1
ER -