Anti-calmodulin acridone derivatives modulate vinblastine resistance in multidrug resistant (MDR) cancer cells

Keyphrases

• Calmodulin 100%
• Chemotherapy Efficacy 33%
• Chemotherapy Treatment 33%
• Cyclization 33%
• Cytotoxicity 33%
• Iodide 33%
• Multidrug Resistance 33%
• Multidrug-resistant 66%
• N-alkylation 33%
• Nucleophilic Substitution 33%
• Resistant Cancer Cells 100%
• Secondary Amines 33%
• Structure-activity Relationship 33%
• Tumor 33%
• Verapamil 33%
• Vinblastine 100%

Pharmacology, Toxicology and Pharmaceutical Science

• Acridone Derivative 100%
• Chemotherapy 25%
• Cyclic AMP Phosphodiesterase 25%
• Malignant Neoplasm 100%
• Neoplasm 25%
• Structure Activity Relationship 25%
• Verapamil 25%
• Vinblastine 100%

Chemistry

• Acridone Derivative 100%
• Calmodulin 100%
• Cyclic Adenosine Monophosphate 33%
• N-alkylation 33%
• Ullmann Reaction 33%
• Verapamil 33%