TY - JOUR
T1 - Antibacterial activities of iron chelators against common nosocomial pathogens
AU - Thompson, Mitchell G.
AU - Corey, Brendan W.
AU - Si, Yuanzheng
AU - Craft, David W.
AU - Zurawski, Daniel V.
PY - 2012/10
Y1 - 2012/10
N2 - The activities of iron chelators (deferoxamine, deferiprone, Apo6619, and VK28) were evaluated against type strains of Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli. Deferiprone, Apo6619, and VK28 each inhibited growth in standard and RPMI tissue culture medium, while deferoxamine had no effect. Additionally, time-kill assays revealed that VK28 had a bacteriostatic effect against S. aureus. Therefore, these newly developed iron chelators might provide a nontraditional approach for treatment of bacterial infections.
AB - The activities of iron chelators (deferoxamine, deferiprone, Apo6619, and VK28) were evaluated against type strains of Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli. Deferiprone, Apo6619, and VK28 each inhibited growth in standard and RPMI tissue culture medium, while deferoxamine had no effect. Additionally, time-kill assays revealed that VK28 had a bacteriostatic effect against S. aureus. Therefore, these newly developed iron chelators might provide a nontraditional approach for treatment of bacterial infections.
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U2 - 10.1128/AAC.01197-12
DO - 10.1128/AAC.01197-12
M3 - Article
C2 - 22850524
AN - SCOPUS:84866334623
SN - 0066-4804
VL - 56
SP - 5419
EP - 5421
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 10
ER -