Antibacterial activities of iron chelators against common nosocomial pathogens

Mitchell G. Thompson; Brendan W. Corey; Yuanzheng Si; David W. Craft; Daniel V. Zurawski

doi:10.1128/AAC.01197-12

Antibacterial activities of iron chelators against common nosocomial pathogens

Mitchell G. Thompson
, Brendan W. Corey
, Yuanzheng Si
, David W. Craft
, Daniel V. Zurawski

Department of Pathology and Laboratory Medicine

Research output: Contribution to journal › Article › peer-review

112 Scopus citations

Abstract

The activities of iron chelators (deferoxamine, deferiprone, Apo6619, and VK28) were evaluated against type strains of Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli. Deferiprone, Apo6619, and VK28 each inhibited growth in standard and RPMI tissue culture medium, while deferoxamine had no effect. Additionally, time-kill assays revealed that VK28 had a bacteriostatic effect against S. aureus. Therefore, these newly developed iron chelators might provide a nontraditional approach for treatment of bacterial infections.

Original language	English (US)
Pages (from-to)	5419-5421
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	56
Issue number	10
DOIs	https://doi.org/10.1128/AAC.01197-12
State	Published - Oct 2012

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

Access to Document

10.1128/AAC.01197-12

Cite this

@article{a159c65cf14b498f858e1283f14333a6,

title = "Antibacterial activities of iron chelators against common nosocomial pathogens",

abstract = "The activities of iron chelators (deferoxamine, deferiprone, Apo6619, and VK28) were evaluated against type strains of Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli. Deferiprone, Apo6619, and VK28 each inhibited growth in standard and RPMI tissue culture medium, while deferoxamine had no effect. Additionally, time-kill assays revealed that VK28 had a bacteriostatic effect against S. aureus. Therefore, these newly developed iron chelators might provide a nontraditional approach for treatment of bacterial infections.",

author = "Thompson, \{Mitchell G.\} and Corey, \{Brendan W.\} and Yuanzheng Si and Craft, \{David W.\} and Zurawski, \{Daniel V.\}",

year = "2012",

month = oct,

doi = "10.1128/AAC.01197-12",

language = "English (US)",

volume = "56",

pages = "5419--5421",

journal = "Antimicrobial agents and chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "10",

}

TY - JOUR

T1 - Antibacterial activities of iron chelators against common nosocomial pathogens

AU - Thompson, Mitchell G.

AU - Corey, Brendan W.

AU - Si, Yuanzheng

AU - Craft, David W.

AU - Zurawski, Daniel V.

PY - 2012/10

Y1 - 2012/10

N2 - The activities of iron chelators (deferoxamine, deferiprone, Apo6619, and VK28) were evaluated against type strains of Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli. Deferiprone, Apo6619, and VK28 each inhibited growth in standard and RPMI tissue culture medium, while deferoxamine had no effect. Additionally, time-kill assays revealed that VK28 had a bacteriostatic effect against S. aureus. Therefore, these newly developed iron chelators might provide a nontraditional approach for treatment of bacterial infections.

AB - The activities of iron chelators (deferoxamine, deferiprone, Apo6619, and VK28) were evaluated against type strains of Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli. Deferiprone, Apo6619, and VK28 each inhibited growth in standard and RPMI tissue culture medium, while deferoxamine had no effect. Additionally, time-kill assays revealed that VK28 had a bacteriostatic effect against S. aureus. Therefore, these newly developed iron chelators might provide a nontraditional approach for treatment of bacterial infections.

UR - https://www.scopus.com/pages/publications/84866334623

UR - https://www.scopus.com/pages/publications/84866334623#tab=citedBy

U2 - 10.1128/AAC.01197-12

DO - 10.1128/AAC.01197-12

M3 - Article

C2 - 22850524

AN - SCOPUS:84866334623

SN - 0066-4804

VL - 56

SP - 5419

EP - 5421

JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

IS - 10

ER -

Antibacterial activities of iron chelators against common nosocomial pathogens

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this