Antibody-catalyzed rearrangement of the peptide bond

Richard A. Gibbs, Scott Taylor, Stephen J. Benkovic

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


The generation of antibodies from a bifunctional cyclic phosphinate transition-state analog provided agents capable of efficiently catalyzing both steps of the overall conversion of a substrate containing an asparaginyl-glycyl sequence through a succinimide intermediate to the products aspartyl-glycyl and the rearranged isoaspartyl-glycyl sequence. This reaction provides a potential means in addition to amide cleavage for the deactivation of protein or peptide biological functions in vivo.

Original languageEnglish (US)
Pages (from-to)803-805
Number of pages3
Issue number5083
StatePublished - Oct 30 1992

All Science Journal Classification (ASJC) codes

  • General


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