TY - JOUR
T1 - Anticonvulsant activity of the glial GABA uptake inhibitor, THAO, in chemical seizures
AU - Gonsalves, Susan F.
AU - Twitchell, Bonnie
AU - Harbaugh, Robert E.
AU - Krogsgaard-Larsen, Povl
AU - Schousboe, Arne
PY - 1989/9/13
Y1 - 1989/9/13
N2 - The antiseizure activity of the glia-selective GABA uptake inhibitor, 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-c]azepin-3-ol (THAO), was evaluated in rats in models of acute chemoconvulsion. In these experiments, intracerebroventricular administration of the drug 30 min prior to testing in doses between 100-750 μg provided protection against maximal pentylenetetrazol seizures and increased the latency to isonicotinic acid hydrazide seizures. Pentylenetetrazol seizure thresholds, in contrast, were not significantly elevated. The ability of THAO to suppress tonic but not generalized minor seizures suggests that it may block seizure spread.
AB - The antiseizure activity of the glia-selective GABA uptake inhibitor, 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-c]azepin-3-ol (THAO), was evaluated in rats in models of acute chemoconvulsion. In these experiments, intracerebroventricular administration of the drug 30 min prior to testing in doses between 100-750 μg provided protection against maximal pentylenetetrazol seizures and increased the latency to isonicotinic acid hydrazide seizures. Pentylenetetrazol seizure thresholds, in contrast, were not significantly elevated. The ability of THAO to suppress tonic but not generalized minor seizures suggests that it may block seizure spread.
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U2 - 10.1016/0014-2999(89)90576-1
DO - 10.1016/0014-2999(89)90576-1
M3 - Article
C2 - 2532604
AN - SCOPUS:0024470501
SN - 0014-2999
VL - 168
SP - 265
EP - 268
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2
ER -