Antigenic and transforming properties of the DB strain of the human polyomavirus BK virus

John E. Tavis; Richard J. Frisque; Duard L. Walker; Frank A. White

doi:10.1016/0042-6822(90)90355-U

Antigenic and transforming properties of the DB strain of the human polyomavirus BK virus

John E. Tavis, Richard J. Frisque, Duard L. Walker, Frank A. White

Biochemistry & Molecular Biology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The analysis of the antigenic and transforming properties of the DB strain of the human polyomavirus BK Virus [BKV(DB)) is presented. Two genomes were molecularly cloned from a single virus preparation and were shown to represent viable virus; one clone [pBKV(DB)dl82) contained an 82 nucleotide deletion in the regulatory region relative to the second clone [pBKV(DB)]; pBKV(DB)dl82 demonstrated enhanced lytic and transforming activities relative to pBKV(DB). BKV(DB) is antigenically distinct from the prototype Gardner strain of BK Virus, and 50 to 60% of the population display serological evidence of BKV(DB) infection. Implications of the existence of antigenic variants on estimation of BK virus prevalence in the population are discussed.

Original language	English (US)
Pages (from-to)	568-572
Number of pages	5
Journal	Virology
Volume	178
Issue number	2
DOIs	https://doi.org/10.1016/0042-6822(90)90355-U
State	Published - Oct 1990

All Science Journal Classification (ASJC) codes

Virology

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10.1016/0042-6822(90)90355-U

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@article{28f7d22c91f147c8875cc1acd7bd6220,

title = "Antigenic and transforming properties of the DB strain of the human polyomavirus BK virus",

abstract = "The analysis of the antigenic and transforming properties of the DB strain of the human polyomavirus BK Virus [BKV(DB)) is presented. Two genomes were molecularly cloned from a single virus preparation and were shown to represent viable virus; one clone [pBKV(DB)dl82) contained an 82 nucleotide deletion in the regulatory region relative to the second clone [pBKV(DB)]; pBKV(DB)dl82 demonstrated enhanced lytic and transforming activities relative to pBKV(DB). BKV(DB) is antigenically distinct from the prototype Gardner strain of BK Virus, and 50 to 60\% of the population display serological evidence of BKV(DB) infection. Implications of the existence of antigenic variants on estimation of BK virus prevalence in the population are discussed.",

author = "Tavis, \{John E.\} and Frisque, \{Richard J.\} and Walker, \{Duard L.\} and White, \{Frank A.\}",

note = "Funding Information: This work was supported by Publtc Health Service Grants CA44970 and Al 1 1217 from the National Cancer Institute and the National Institute of Allergy and Infectious Diseases, respectively, by a Sigma Xi Grant-In-Aid of Research, and by a grant from the Tracy Ruhrup Memorial Fund. J.E.T. was supported by a National Science Foundation Graduate Fellowship.",

year = "1990",

month = oct,

doi = "10.1016/0042-6822(90)90355-U",

language = "English (US)",

volume = "178",

pages = "568--572",

journal = "Virology",

issn = "0042-6822",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - Antigenic and transforming properties of the DB strain of the human polyomavirus BK virus

AU - Tavis, John E.

AU - Frisque, Richard J.

AU - Walker, Duard L.

AU - White, Frank A.

N1 - Funding Information: This work was supported by Publtc Health Service Grants CA44970 and Al 1 1217 from the National Cancer Institute and the National Institute of Allergy and Infectious Diseases, respectively, by a Sigma Xi Grant-In-Aid of Research, and by a grant from the Tracy Ruhrup Memorial Fund. J.E.T. was supported by a National Science Foundation Graduate Fellowship.

PY - 1990/10

Y1 - 1990/10

N2 - The analysis of the antigenic and transforming properties of the DB strain of the human polyomavirus BK Virus [BKV(DB)) is presented. Two genomes were molecularly cloned from a single virus preparation and were shown to represent viable virus; one clone [pBKV(DB)dl82) contained an 82 nucleotide deletion in the regulatory region relative to the second clone [pBKV(DB)]; pBKV(DB)dl82 demonstrated enhanced lytic and transforming activities relative to pBKV(DB). BKV(DB) is antigenically distinct from the prototype Gardner strain of BK Virus, and 50 to 60% of the population display serological evidence of BKV(DB) infection. Implications of the existence of antigenic variants on estimation of BK virus prevalence in the population are discussed.

AB - The analysis of the antigenic and transforming properties of the DB strain of the human polyomavirus BK Virus [BKV(DB)) is presented. Two genomes were molecularly cloned from a single virus preparation and were shown to represent viable virus; one clone [pBKV(DB)dl82) contained an 82 nucleotide deletion in the regulatory region relative to the second clone [pBKV(DB)]; pBKV(DB)dl82 demonstrated enhanced lytic and transforming activities relative to pBKV(DB). BKV(DB) is antigenically distinct from the prototype Gardner strain of BK Virus, and 50 to 60% of the population display serological evidence of BKV(DB) infection. Implications of the existence of antigenic variants on estimation of BK virus prevalence in the population are discussed.

UR - https://www.scopus.com/pages/publications/0025089072

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U2 - 10.1016/0042-6822(90)90355-U

DO - 10.1016/0042-6822(90)90355-U

M3 - Article

C2 - 2171195

AN - SCOPUS:0025089072

SN - 0042-6822

VL - 178

SP - 568

EP - 572

JO - Virology

JF - Virology

IS - 2

ER -

Antigenic and transforming properties of the DB strain of the human polyomavirus BK virus

Abstract

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