Antiproliferatives and Transplantation

Robert Donovan; Howard Eisen; Omaima Ali

doi:10.1007/164_2021_556

Antiproliferatives and Transplantation

Robert Donovan
, Howard Eisen
, Omaima Ali

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Antiproliferative agents include Mycophenolic acid and Azathioprine (which is less commonly used unless in certain conditions). They were initially identified for use in autoimmune and cancer research due to their role in disruption of cellular replication. They have now become the cornerstone of antirejection maintenance therapy in solid organ transplant. In this chapter we will describe the major times that lead to discovery, mechanisms of action, side effects, use during pregnancy and the major clinical trials.

Original language	English (US)
Title of host publication	Handbook of Experimental Pharmacology
Publisher	Springer Science and Business Media Deutschland GmbH
Pages	39-52
Number of pages	14
DOIs	https://doi.org/10.1007/164_2021_556
State	Published - 2022

Publication series

Name	Handbook of Experimental Pharmacology
Volume	272
ISSN (Print)	0171-2004
ISSN (Electronic)	1865-0325

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Biochemistry
Pharmacology, Toxicology and Pharmaceutics(all)

Access to Document

10.1007/164_2021_556

Cite this

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abstract = "Antiproliferative agents include Mycophenolic acid and Azathioprine (which is less commonly used unless in certain conditions). They were initially identified for use in autoimmune and cancer research due to their role in disruption of cellular replication. They have now become the cornerstone of antirejection maintenance therapy in solid organ transplant. In this chapter we will describe the major times that lead to discovery, mechanisms of action, side effects, use during pregnancy and the major clinical trials.",

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AU - Eisen, Howard

AU - Ali, Omaima

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M3 - Chapter

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Antiproliferatives and Transplantation

Abstract

Publication series

UN SDGs

All Science Journal Classification (ASJC) codes

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