TY - JOUR
T1 - Antitumor activity of nifurtimox observed in a patient with neuroblastoma
AU - Saulnier Sholler, Giselle L.
AU - Kalkunte, Satyan
AU - Greenlaw, Carla
AU - McCarten, Kathleen
AU - Forman, Edwin
PY - 2006/10
Y1 - 2006/10
N2 - BACKGROUND: Chemotherapy-resistant neuroblastoma is a difficult disease to treat with poor survival. OBSERVATIONS: We treated a patient with neuroblastoma who had progressed on conventional chemotherapy. This 5-year-old girl with chemotherapy-resistant neuroblastoma developed Chagas disease at the start of salvage chemotherapy for which she was also started on nifurtimox. The neuroblastoma response to these treatments resulted in clinical remission. In vitro, treatment of a neuroblastoma cell line with nifurtimox resulted in decreased cell viability whereas no effect was seen on an endothelial cell line. CONCLUSIONS: Nifurtimox shows promise as a potential new treatment for neuroblastoma and warrants further testing.
AB - BACKGROUND: Chemotherapy-resistant neuroblastoma is a difficult disease to treat with poor survival. OBSERVATIONS: We treated a patient with neuroblastoma who had progressed on conventional chemotherapy. This 5-year-old girl with chemotherapy-resistant neuroblastoma developed Chagas disease at the start of salvage chemotherapy for which she was also started on nifurtimox. The neuroblastoma response to these treatments resulted in clinical remission. In vitro, treatment of a neuroblastoma cell line with nifurtimox resulted in decreased cell viability whereas no effect was seen on an endothelial cell line. CONCLUSIONS: Nifurtimox shows promise as a potential new treatment for neuroblastoma and warrants further testing.
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U2 - 10.1097/01.mph.0000212994.56812.f2
DO - 10.1097/01.mph.0000212994.56812.f2
M3 - Article
C2 - 17023833
AN - SCOPUS:33749571402
SN - 1077-4114
VL - 28
SP - 693
EP - 695
JO - Journal of pediatric hematology/oncology
JF - Journal of pediatric hematology/oncology
IS - 10
ER -
