TY - JOUR
T1 - Apoptosis
T2 - Molecules and mechanisms
AU - Konopleva, Marina
AU - Zhao, Shourong
AU - Xie, Zhong
AU - Segall, Harry
AU - Younes, Anas
AU - Claxton, David F.
AU - Estrov, Zeev
AU - Kornblau, Steven M.
AU - Andreeff, Michael
PY - 1999
Y1 - 1999
N2 - This review of the molecules and pathways involved in programmed cell death (apoptosis) discriminates triggers of apoptosis (e.g. chemotherapy, radiation, Fas ligation), modulators of apoptosis (e.g. Bcl-2 family members, Bcl-2 interacting proteins, Apafs, IAPs, and Fas/FasL modulators including FLICE and FLIPs), effectors (caspases 1-13) and cleavage substrates (e.g. PARP). Special consideration is given to the structure-function relationship of Bcl-2 family members and to their post-transcriptional modification. Brief references are made to the role of apoptotic pathway in leukemias and lymphomas and to strategies of modulating apoptotic pathways.
AB - This review of the molecules and pathways involved in programmed cell death (apoptosis) discriminates triggers of apoptosis (e.g. chemotherapy, radiation, Fas ligation), modulators of apoptosis (e.g. Bcl-2 family members, Bcl-2 interacting proteins, Apafs, IAPs, and Fas/FasL modulators including FLICE and FLIPs), effectors (caspases 1-13) and cleavage substrates (e.g. PARP). Special consideration is given to the structure-function relationship of Bcl-2 family members and to their post-transcriptional modification. Brief references are made to the role of apoptotic pathway in leukemias and lymphomas and to strategies of modulating apoptotic pathways.
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U2 - 10.1007/978-1-4615-4811-9_24
DO - 10.1007/978-1-4615-4811-9_24
M3 - Article
C2 - 10500797
AN - SCOPUS:0032610936
SN - 0065-2598
VL - 457
SP - 217
EP - 236
JO - Advances in experimental medicine and biology
JF - Advances in experimental medicine and biology
ER -