Application of atomic force microscope to the study of bio-cells

Bernhard Tittmann, Jikai Du, Anne Ebert, Brian Piccione

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations


Ultrasonic atomic force microscopy (U-AFM) was used to image the elastic properties of hamster kidney (BHK) cells. Force-distance curves and finite element analysis were also used in this work assist in the description of the U-AFM images. These tools helped explain the differences in contrast seen from the center to the edge of the cell. The explanation of the U-AFM image contrast will lead to more analytical tools to investigate both nonviable and viable materials. Improvement of our system for living cell (in a culture) imaging is also discussed.

Original languageEnglish (US)
Article number02
Pages (from-to)11-18
Number of pages8
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 2005
EventHealth Monitoring and Smart Nondestructive Evaluation of Structural and Biological Systems IV - San Diego, CA, United States
Duration: Mar 7 2005Mar 9 2005

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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