In contrast to conventional stem cell transplantation which utilizes high-dose chemotherapy and/or total body irradiation as a conditioning regimen, non-myeloablative stem cell transplantation (NST) uses mainly immunosuppressants. NST is now being used to treat solid tumors, as it greatly alleviates regimen-related toxicity. NST, which utilizes the graft-versus-tumor effect as an anti-tumor weapon, is considered to be one type of immunotherapy. Ongoing clinical studies in the U.S. and Europe as well as in Japan are producing promising results for renal cell carcinoma and other tumors.
|Number of pages
|Published - 2001
All Science Journal Classification (ASJC) codes
- Cancer Research
- Immunology and Allergy