TY - JOUR
T1 - Application of the second-order fluid model to estimate factors affecting clearance of small and middle uremic molecules using combined ultrafiltration and diffusion processes
AU - Bhatti, Kaleemullah
AU - Siddiqui, Abdul Majeed
AU - Bano, Zarqa
N1 - Publisher Copyright:
© 2023 The Physical Society of the Republic of China (Taiwan)
PY - 2023/12
Y1 - 2023/12
N2 - Uremic solute transport in a hollow fiber dialyzer is investigated theoretically with combined ultrafiltration and diffusion with the assumption of uniform ultrafiltration velocity and other standard assumptions. A numerical solution for concentration profiles in the blood compartment is obtained by using an implicit finite difference scheme implemented with MATLAB R2018a. The resulting system of linear equations is solved using another Matlab script implementing the Gauss–Seidel method. Uremic clearance of three solutes viz. urea, creatinine, and vitamin B-12 are considered. Different factors affecting Cl were observed and discussed in detail. Those factors include operating conditions (inlet blood flow rate, ultrafiltration velocity, etc.), dialyzer geometry (length, radius, number of fibers), and fluid parameters. The solute clearance can be maximized for a suitable set of values of these parameters.
AB - Uremic solute transport in a hollow fiber dialyzer is investigated theoretically with combined ultrafiltration and diffusion with the assumption of uniform ultrafiltration velocity and other standard assumptions. A numerical solution for concentration profiles in the blood compartment is obtained by using an implicit finite difference scheme implemented with MATLAB R2018a. The resulting system of linear equations is solved using another Matlab script implementing the Gauss–Seidel method. Uremic clearance of three solutes viz. urea, creatinine, and vitamin B-12 are considered. Different factors affecting Cl were observed and discussed in detail. Those factors include operating conditions (inlet blood flow rate, ultrafiltration velocity, etc.), dialyzer geometry (length, radius, number of fibers), and fluid parameters. The solute clearance can be maximized for a suitable set of values of these parameters.
UR - http://www.scopus.com/inward/record.url?scp=85177870004&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85177870004&partnerID=8YFLogxK
U2 - 10.1016/j.cjph.2023.08.018
DO - 10.1016/j.cjph.2023.08.018
M3 - Article
AN - SCOPUS:85177870004
SN - 0577-9073
VL - 86
SP - 458
EP - 468
JO - Chinese Journal of Physics
JF - Chinese Journal of Physics
ER -