TY - JOUR
T1 - Applications of Discrete Molecular Dynamics in biology and medicine
AU - Proctor, Elizabeth A.
AU - Dokholyan, Nikolay V.
N1 - Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Discrete Molecular Dynamics (DMD) is a physics-based simulation method using discrete energetic potentials rather than traditional continuous potentials, allowing microsecond time scale simulations of biomolecular systems to be performed on personal computers rather than supercomputers or specialized hardware. With the ongoing explosion in processing power even in personal computers, applications of DMD have similarly multiplied. In the past two years, researchers have used DMD to model structures of disease-implicated protein folding intermediates, study assembly of protein complexes, predict protein-protein binding conformations, engineer rescue mutations in disease-causative protein mutants, design a protein conformational switch to control cell signaling, and describe the behavior of polymeric dispersants for environmental cleanup of oil spills, among other innovative applications.
AB - Discrete Molecular Dynamics (DMD) is a physics-based simulation method using discrete energetic potentials rather than traditional continuous potentials, allowing microsecond time scale simulations of biomolecular systems to be performed on personal computers rather than supercomputers or specialized hardware. With the ongoing explosion in processing power even in personal computers, applications of DMD have similarly multiplied. In the past two years, researchers have used DMD to model structures of disease-implicated protein folding intermediates, study assembly of protein complexes, predict protein-protein binding conformations, engineer rescue mutations in disease-causative protein mutants, design a protein conformational switch to control cell signaling, and describe the behavior of polymeric dispersants for environmental cleanup of oil spills, among other innovative applications.
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U2 - 10.1016/j.sbi.2015.11.001
DO - 10.1016/j.sbi.2015.11.001
M3 - Review article
C2 - 26638022
AN - SCOPUS:84948170736
SN - 0959-440X
VL - 37
SP - 9
EP - 13
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
ER -