Approaching the mechanism of protein transport across the ER membrane

Tom A. Rapoport; Melissa M. Rolls; Berit Jungnickel

doi:10.1016/S0955-0674(96)80027-5

Approaching the mechanism of protein transport across the ER membrane

Tom A. Rapoport, Melissa M. Rolls, Berit Jungnickel

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

Since the identification of essential protein-translocation components in the endoplasmic reticulum membrane, research efforts have concentrated on the elucidation of the molecular mechanism of protein transport across this membrane. Recent results have provided new information as to how proteins are targeted to, and inserted into, the translocation site during translation. Post-translational translocation has also been examined and is distinct from cotranslational translocation with respect to the mechanism and membrane protein components involved.

Original language	English (US)
Pages (from-to)	499-504
Number of pages	6
Journal	Current Opinion in Cell Biology
Volume	8
Issue number	4
DOIs	https://doi.org/10.1016/S0955-0674(96)80027-5
State	Published - Aug 1996

All Science Journal Classification (ASJC) codes

Cell Biology

Access to Document

10.1016/S0955-0674(96)80027-5

Cite this

@article{7b9d2315bdba47eeb7616f4eb00803e6,

title = "Approaching the mechanism of protein transport across the ER membrane",

abstract = "Since the identification of essential protein-translocation components in the endoplasmic reticulum membrane, research efforts have concentrated on the elucidation of the molecular mechanism of protein transport across this membrane. Recent results have provided new information as to how proteins are targeted to, and inserted into, the translocation site during translation. Post-translational translocation has also been examined and is distinct from cotranslational translocation with respect to the mechanism and membrane protein components involved.",

author = "Rapoport, {Tom A.} and Rolls, {Melissa M.} and Berit Jungnickel",

note = "Funding Information: We apologize to our colleagues whose work could not be quoted because of space limitations. We thank John Young, Kristen Verhey, Wahher Mothes, and Peter Walter for critical reading of the manuscript. The work in the authors' laboratory is supported by grants from the National Institutes of Health and the Human Science Frontier Program. MM Rolls is a Howard Hughes Predoctoral Fellow.",

year = "1996",

month = aug,

doi = "10.1016/S0955-0674(96)80027-5",

language = "English (US)",

volume = "8",

pages = "499--504",

journal = "Current Opinion in Cell Biology",

issn = "0955-0674",

publisher = "Elsevier Limited",

number = "4",

}

TY - JOUR

T1 - Approaching the mechanism of protein transport across the ER membrane

AU - Rapoport, Tom A.

AU - Rolls, Melissa M.

AU - Jungnickel, Berit

N1 - Funding Information: We apologize to our colleagues whose work could not be quoted because of space limitations. We thank John Young, Kristen Verhey, Wahher Mothes, and Peter Walter for critical reading of the manuscript. The work in the authors' laboratory is supported by grants from the National Institutes of Health and the Human Science Frontier Program. MM Rolls is a Howard Hughes Predoctoral Fellow.

PY - 1996/8

Y1 - 1996/8

N2 - Since the identification of essential protein-translocation components in the endoplasmic reticulum membrane, research efforts have concentrated on the elucidation of the molecular mechanism of protein transport across this membrane. Recent results have provided new information as to how proteins are targeted to, and inserted into, the translocation site during translation. Post-translational translocation has also been examined and is distinct from cotranslational translocation with respect to the mechanism and membrane protein components involved.

AB - Since the identification of essential protein-translocation components in the endoplasmic reticulum membrane, research efforts have concentrated on the elucidation of the molecular mechanism of protein transport across this membrane. Recent results have provided new information as to how proteins are targeted to, and inserted into, the translocation site during translation. Post-translational translocation has also been examined and is distinct from cotranslational translocation with respect to the mechanism and membrane protein components involved.

UR - http://www.scopus.com/inward/record.url?scp=0030222331&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030222331&partnerID=8YFLogxK

U2 - 10.1016/S0955-0674(96)80027-5

DO - 10.1016/S0955-0674(96)80027-5

M3 - Article

C2 - 8791447

AN - SCOPUS:0030222331

SN - 0955-0674

VL - 8

SP - 499

EP - 504

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

IS - 4

ER -

Approaching the mechanism of protein transport across the ER membrane

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this