Aptamer-based molecular recognition for biosensor development

Jing Zhou, Mark R. Battig, Yong Wang

Research output: Contribution to journalReview articlepeer-review

121 Scopus citations


Nucleic acid aptamers are an emerging class of synthetic ligands and have recently attracted significant attention in numerous fields. One is in biosensor development. In principle, nucleic acid aptamers can be discovered to recognize any molecule of interest with high affinity and specificity. In addition, unlike most ligands evolved in nature, synthetic nucleic acid aptamers are usually tolerant of harsh chemical, physical, and biological conditions. These distinguished characteristics make aptamers attractive molecular recognition ligands for biosensing applications. This review first concisely introduces methods for aptamer discovery including upstream selection and downstream truncation, then discusses aptamer-based biosensor development from the viewpoint of signal production.

Original languageEnglish (US)
Pages (from-to)2471-2480
Number of pages10
JournalAnalytical and Bioanalytical Chemistry
Issue number6
StatePublished - Nov 2010

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry


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