Aptamer-Functionalized Hydrogel for Self-Programmed Protein Release via Sequential Photoreaction and Hybridization

Jinping Lai, Pinliang Jiang, Erin R. Gaddes, Nan Zhao, Lidya Abune, Yong Wang

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


A dynamic hydrogel that sequentially responds to two independent but interrelated physical and biomolecular signals was reported in this work. Once hit by an external light signal, an immobilized internal molecular signal is activated and freed via photoreaction; and subsequently the freed molecular signal works as a self-programming factor of the hydrogel to induce the dissociation of a biomolecular complex to release protein via a hybridization reaction. Notably, pulsatile external light input can be converted to periodical protein output from the hydrogel to regulate cell migration. Thus, this hydrogel holds potential as a self-programming platform for biological and biomedical applications such as controlled release of bioactive substances.

Original languageEnglish (US)
Pages (from-to)5850-5857
Number of pages8
JournalChemistry of Materials
Issue number14
StatePublished - Jul 25 2017

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • General Chemical Engineering
  • Materials Chemistry


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