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ARID1A-mutated ovarian cancers depend on HDAC6 activity
Benjamin G. Bitler
, Shuai Wu
, Pyoung Hwa Park
, Yang Hai
, Katherine M. Aird
, Yemin Wang
, Yali Zhai
, Andrew V. Kossenkov
, Ana Vara-Ailor
, Frank J. Rauscher
, Weiping Zou
, David W. Speicher
, David G. Huntsman
, Jose R. Conejo-Garcia
, Kathleen R. Cho
, David W. Christianson
, Rugang Zhang
Penn State Cancer Institute
Cancer Institute, Mechanisms of Carcinogenesis
Research output
:
Contribution to journal
›
Article
›
peer-review
187
Scopus citations
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Keyphrases
Apoptosis
22%
ARID1A
100%
ARID1A mutation
22%
Chromatin Remodelers
11%
Epigenetic Regulators
11%
Histone Deacetylase 6 (HDAC6)
100%
Human Cancer
11%
Mutually Exclusive
11%
Ovarian Cancer
100%
Pharmacological Inhibitors
11%
Post-translational Modification
11%
Pro-apoptotic
11%
Small Molecule Inhibitors
11%
SWItch/Sucrose Non-fermentable
11%
Therapeutic Approaches
11%
Therapeutic Strategies
11%
TP53 mutation
11%
Transcriptional Repression
11%
Tumor
22%
Biochemistry, Genetics and Molecular Biology
ARID1A
100%
Chromatin Remodeling
9%
Epigenetics
9%
Genetic Trait
9%
HDAC6
100%
P53
18%
Posttranslational Modification
9%
Programmed Cell Death
18%
Small Molecule
9%
SWI/SNF
9%
Wild Type
9%
Pharmacology, Toxicology and Pharmaceutical Science
Histone Deacetylase 6
100%