Aromatase inhibitors in clinical practice: Current status and a look to the future

H. A. Harvey

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


Aromatase inhibitors are a new class of agents that are of considerable interest for potential use as palliative therapy for hormone-dependent metastatic breast cancer in postmenopausal women. In the postmenopausal or castrate female, the process of aromatization accounts for the majority of circulating, biologically active estrogens. This report presents a clinical perspective on some of the most recent information concerning the biology and pharmacology of the aromatase enzyme and highlights the development of newer aromatase inhibitors with important therapeutic potential. Clinical questions addressed include the selection of aromarase inhibitors, the selection of the most appropriate patients for therapy with these new agents, and the positioning of these new agents with respect to other forms of endocrine therapy for breast cancer. Finally, we shall consider areas for future investigation of possible new indications for these agents in clinical medicine.

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
JournalSeminars in oncology
Issue number4 SUPPL. 9
StatePublished - Oct 4 1996

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology


Dive into the research topics of 'Aromatase inhibitors in clinical practice: Current status and a look to the future'. Together they form a unique fingerprint.

Cite this