Arterial dilatory reserve in congestive heart failure

Robert Zelis; Daniel Hayoz; Helmut Drexler; Thomas Munzel; Burkhardt Hornig; Andreas M. Zeiher; Hanjorg Just; Hans R. Brunner

doi:10.1097/00004872-199208001-00017

Arterial dilatory reserve in congestive heart failure

Robert Zelis, Daniel Hayoz, Helmut Drexler, Thomas Munzel, Burkhardt Hornig, Andreas M. Zeiher, Hanjorg Just, Hans R. Brunner

Department of Medicine

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Aim: The purpose of this study was to determine whether there are abnormalities in flow-mediated large vessel relaxation in patients with congestive heart failure (CHF). Methods: The radial arterial diameter and flow responses upon the release of 10min of forearm arterial occlusion (reactive hyperemia) were measured with ultrasound and Doppler devices. Results: In patients with CHF there was a 26% reduction in peak blood flow (P = 0.09) compared to age-matched controls. However, the increase in arterial diameter that followed the peak blood flow was reduced by 49% in CHF (P < 0.01). Conclusions: The causes of the abnormal flow-mediated large artery relaxation in CHF are unclear; both structural and endothelial abnormalities may contribute.

Original language	English (US)
Pages (from-to)	S65-S67
Journal	Journal of hypertension
Volume	10
DOIs	https://doi.org/10.1097/00004872-199208001-00017
State	Published - Aug 1992

All Science Journal Classification (ASJC) codes

Internal Medicine
Physiology
Cardiology and Cardiovascular Medicine

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10.1097/00004872-199208001-00017

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title = "Arterial dilatory reserve in congestive heart failure",

abstract = "Aim: The purpose of this study was to determine whether there are abnormalities in flow-mediated large vessel relaxation in patients with congestive heart failure (CHF). Methods: The radial arterial diameter and flow responses upon the release of 10min of forearm arterial occlusion (reactive hyperemia) were measured with ultrasound and Doppler devices. Results: In patients with CHF there was a 26% reduction in peak blood flow (P = 0.09) compared to age-matched controls. However, the increase in arterial diameter that followed the peak blood flow was reduced by 49% in CHF (P < 0.01). Conclusions: The causes of the abnormal flow-mediated large artery relaxation in CHF are unclear; both structural and endothelial abnormalities may contribute.",

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doi = "10.1097/00004872-199208001-00017",

language = "English (US)",

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pages = "S65--S67",

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T1 - Arterial dilatory reserve in congestive heart failure

AU - Zelis, Robert

AU - Hayoz, Daniel

AU - Drexler, Helmut

AU - Munzel, Thomas

AU - Hornig, Burkhardt

AU - Zeiher, Andreas M.

AU - Just, Hanjorg

AU - Brunner, Hans R.

PY - 1992/8

Y1 - 1992/8

N2 - Aim: The purpose of this study was to determine whether there are abnormalities in flow-mediated large vessel relaxation in patients with congestive heart failure (CHF). Methods: The radial arterial diameter and flow responses upon the release of 10min of forearm arterial occlusion (reactive hyperemia) were measured with ultrasound and Doppler devices. Results: In patients with CHF there was a 26% reduction in peak blood flow (P = 0.09) compared to age-matched controls. However, the increase in arterial diameter that followed the peak blood flow was reduced by 49% in CHF (P < 0.01). Conclusions: The causes of the abnormal flow-mediated large artery relaxation in CHF are unclear; both structural and endothelial abnormalities may contribute.

AB - Aim: The purpose of this study was to determine whether there are abnormalities in flow-mediated large vessel relaxation in patients with congestive heart failure (CHF). Methods: The radial arterial diameter and flow responses upon the release of 10min of forearm arterial occlusion (reactive hyperemia) were measured with ultrasound and Doppler devices. Results: In patients with CHF there was a 26% reduction in peak blood flow (P = 0.09) compared to age-matched controls. However, the increase in arterial diameter that followed the peak blood flow was reduced by 49% in CHF (P < 0.01). Conclusions: The causes of the abnormal flow-mediated large artery relaxation in CHF are unclear; both structural and endothelial abnormalities may contribute.

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Arterial dilatory reserve in congestive heart failure

Abstract

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