Arterial dilatory reserve in congestive heart failure

Robert Zelis, Daniel Hayoz, Helmut Drexler, Thomas Munzel, Burkhardt Hornig, Andreas M. Zeiher, Hanjorg Just, Hans R. Brunner

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Aim: The purpose of this study was to determine whether there are abnormalities in flow-mediated large vessel relaxation in patients with congestive heart failure (CHF). Methods: The radial arterial diameter and flow responses upon the release of 10min of forearm arterial occlusion (reactive hyperemia) were measured with ultrasound and Doppler devices. Results: In patients with CHF there was a 26% reduction in peak blood flow (P = 0.09) compared to age-matched controls. However, the increase in arterial diameter that followed the peak blood flow was reduced by 49% in CHF (P < 0.01). Conclusions: The causes of the abnormal flow-mediated large artery relaxation in CHF are unclear; both structural and endothelial abnormalities may contribute.

Original languageEnglish (US)
Pages (from-to)S65-S67
JournalJournal of hypertension
StatePublished - Aug 1992

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine


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